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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   FLNA Antibody (Y1046)   

FLNA Antibody (Y1046)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

  • WB - FLNA Antibody (Y1046) AP7770a
    FLNA Antibody (Y1046) (Cat.#AP7770a) western blot analysis in U251 cell line lysates (35ug/lane).This demonstrates the FLNA antibody detected the FLNA protein (arrow).
  • IHC-P - FLNA Antibody (Y1046) AP7770a
    FLNA Antibody (Y1046) (Cat. #AP7770a)immunohistochemistry analysis in formalin fixed and paraffin embedded human skeletal muscle followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of FLNA Antibody (Y1046) for immunohistochemistry. Clinical relevance has not been evaluated.
  • IF - FLNA Antibody (Y1046) AP7770a
    Confocal immunofluorescent analysis of FLNA Antibody (Y1046)(Cat#AP7770a) with Hela cell followed by Alexa Fluor 488-conjugated goat anti-rabbit lgG (green).DAPI was used to stain the cell nuclear (blue).
  • FC - FLNA Antibody (Y1046) AP7770a
    FLNA Antibody (Y1046) (Cat. #AP7770a) flow cytometric analysis of U251 cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P21333
Other Accession Q8BTM8
Reactivity Human
Predicted Mouse
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 280739 Da
Antigen Region 1025-1054 aa
Additional Information
Gene ID 2316
Other Names Filamin-A, FLN-A, Actin-binding protein 280, ABP-280, Alpha-filamin, Endothelial actin-binding protein, Filamin-1, Non-muscle filamin, FLNA, FLN, FLN1
Target/Specificity This FLNA antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1025-1054 amino acids from human FLNA.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsFLNA Antibody (Y1046) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Synonyms FLN, FLN1
Function Promotes orthogonal branching of actin filaments and links actin filaments to membrane glycoproteins. Anchors various transmembrane proteins to the actin cytoskeleton and serves as a scaffold for a wide range of cytoplasmic signaling proteins. Interaction with FLNA may allow neuroblast migration from the ventricular zone into the cortical plate. Tethers cell surface- localized furin, modulates its rate of internalization and directs its intracellular trafficking (By similarity). Involved in ciliogenesis.
Cellular Location Cytoplasm, cell cortex. Cytoplasm, cytoskeleton
Tissue Location Ubiquitous.
Research Areas
Citations (0)

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Actin-binding protein 280, or filamin, is a 280-kD protein that crosslinks actin filaments into orthogonal networks in cortical cytoplasm and participates in the anchoring of membrane proteins for the actin cytoskeleton. Remodeling of the cytoskeleton is central to the modulation of cell shape and migration. Filamin A, encoded by the FLNA gene, is a widely expressed protein that regulates reorganization of the actin cytoskeleton by interacting with integrins, transmembrane receptor complexes, and second messengers.


Ravid,D., Exp. Cell Res. 314 (15), 2762-2773 (2008)
Maceyka,M., Mol. Cell. Biol. 28 (18), 5687-5697 (2008)

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$ 295.00
$ 99.00
Cat# AP7770a
(40 western blots)
Availability: In Stock
Bulk Size
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