|Application ||WB, IHC-P, FC, IF, E|
|Calculated MW||26959 Da|
|Antigen Region||84-115 aa|
|Other Names||Beta-nerve growth factor, Beta-NGF, NGF, NGFB|
|Target/Specificity||This NGFB antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 84-115 amino acids from the Central region of human NGFB.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||NGFB Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Nerve growth factor is important for the development and maintenance of the sympathetic and sensory nervous systems. Extracellular ligand for the NTRK1 and NGFR receptors, activates cellular signaling cascades through those receptor tyrosine kinase to regulate neuronal proliferation, differentiation and survival. Inhibits metalloproteinase dependent proteolysis of platelet glycoprotein VI (PubMed:20164177).|
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Provided below are standard protocols that you may find useful for product applications.
NGFB is a member of the NGF-beta family. It is a secreted protein which homodimerizes and is incorporated into a larger complex. This protein has nerve growth stimulating activity and the complex is involved in the regulation of growth and the differentiation of sympathetic and certain sensory neurons. Mutations in the gene encoding NGFB have been associated with hereditary sensory and autonomic neuropathy, type 5 (HSAN5), and dysregulation of the gene's expression is associated with allergic rhinitis.
Lang,U.E., Pharmacopsychiatry 41 (5), 196-199 (2008)
Truzzi,F., J. Invest. Dermatol. 128 (8), 2031-2040 (2008)
MacGrogan,D., J. Neurochem. 59 (4), 1381-1391 (1992)
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