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PR48 Antibody (N-term)

Purified Rabbit Polyclonal Antibody (Pab)

     
  • WB - PR48 Antibody (N-term) AP7772a
    Western blot analysis of PR48 antibody (N-term) (Cat. #AP7772a) in 293, NCI-H460, Hela, K562 and HL60 cell line lysates (35ug/lane). PR48 (arrow) was detected using the purified Pab.
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, E
Primary Accession Q9Y5P8
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit IgG
Calculated MW 65061 Da
Antigen Region 25-54 aa
Additional Information
Gene ID 28227
Other Names Serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit beta, PP2A subunit B isoform PR48, Protein phosphatase 2A 48 kDa regulatory subunit, PPP2R3B, PPP2R3L
Target/Specificity This PR48 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 25-54 amino acids from the N-terminal region of human PR48.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsPR48 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name PPP2R3B
Synonyms PPP2R3L
Function The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment.
Cellular Location Nucleus.
Research Areas
Citations (0)
citation

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Background

Protein phosphatase 2 (formerly named type 2A) is one of the four major Ser/Thr phosphatases and is implicated in the negative control of cell growth and division. Protein phosphatase 2 holoenzymes are heterotrimeric proteins composed of a structural subunit A, a catalytic subunit C, and a regulatory subunit B. These different regulatory subunits confer distinct enzymatic specificities and intracellular localizations to the holozenzyme. This protein belongs to the B'' family. The B'' family has been further divided into subfamilies. This protein belongs to the beta subfamily of regulatory subunit B''.

References

Stevens,I., Eur. J. Biochem. 270 (2), 376-387 (2003)
Yokoyama,N., Oncogene 20 (42), 6057-6065 (2001)
Yan,Z., Mol. Cell. Biol. 20 (3), 1021-1029 (2000)

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$ 365.00
$ 140.00
Cat# AP7772a
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