|Application ||WB, E|
|Calculated MW||65061 Da|
|Antigen Region||25-54 aa|
|Other Names||Serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit beta, PP2A subunit B isoform PR48, Protein phosphatase 2A 48 kDa regulatory subunit, PPP2R3B, PPP2R3L|
|Target/Specificity||This PR48 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 25-54 amino acids from the N-terminal region of human PR48.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||PR48 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment.|
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Provided below are standard protocols that you may find useful for product applications.
Protein phosphatase 2 (formerly named type 2A) is one of the four major Ser/Thr phosphatases and is implicated in the negative control of cell growth and division. Protein phosphatase 2 holoenzymes are heterotrimeric proteins composed of a structural subunit A, a catalytic subunit C, and a regulatory subunit B. These different regulatory subunits confer distinct enzymatic specificities and intracellular localizations to the holozenzyme. This protein belongs to the B'' family. The B'' family has been further divided into subfamilies. This protein belongs to the beta subfamily of regulatory subunit B''.
Stevens,I., Eur. J. Biochem. 270 (2), 376-387 (2003)
Yokoyama,N., Oncogene 20 (42), 6057-6065 (2001)
Yan,Z., Mol. Cell. Biol. 20 (3), 1021-1029 (2000)
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