|Application ||WB, IHC-P, E|
|Other Accession||Q9R1E9, O19113, P29268, O18739, NP_001892|
|Predicted||Bovine, Mouse, Pig, Rat|
|Calculated MW||38091 Da|
|Antigen Region||315-349 aa|
|Other Names||Connective tissue growth factor, CCN family member 2, Hypertrophic chondrocyte-specific protein 24, Insulin-like growth factor-binding protein 8, IBP-8, IGF-binding protein 8, IGFBP-8, CTGF, CCN2, HCS24, IGFBP8|
|Target/Specificity||This CTGF antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 315-349 amino acids from the C-terminal region of human CTGF.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||CTGF Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||CCN2, HCS24, IGFBP8|
|Function||Major connective tissue mitoattractant secreted by vascular endothelial cells. Promotes proliferation and differentiation of chondrocytes. Mediates heparin- and divalent cation-dependent cell adhesion in many cell types including fibroblasts, myofibroblasts, endothelial and epithelial cells. Enhances fibroblast growth factor-induced DNA synthesis.|
|Cellular Location||Secreted, extracellular space, extracellular matrix. Secreted|
|Tissue Location||Expressed in bone marrow and thymic cells. Also expressed one of two Wilms tumors tested|
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Provided below are standard protocols that you may find useful for product applications.
Connective tissue growth factor (CTGF), a member of the CCN family of secreted matricellular proteins, regulates fibrosis, angiogenesis, cell proliferation, apoptosis, tumor growth, and metastasis.
Li,M.H., Mol. Cancer Res. 6 (10), 1649-1656 (2008)
Bogatkevich,G.S., Am. J. Physiol. Lung Cell Mol. Physiol. 295 (4), L603-L611 (2008)
Zhang,P., Tohoku J. Exp. Med. 215 (3), 199-206 (2008)
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