|Application ||IHC-P, E|
|Calculated MW||186796 Da|
|Antigen Region||295-323 aa|
|Other Names||Latent-transforming growth factor beta-binding protein 1, LTBP-1, Transforming growth factor beta-1-binding protein 1, TGF-beta1-BP-1, LTBP1|
|Target/Specificity||This LTBP1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 295-323 amino acids from the N-terminal region of human LTBP1.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||LTBP1 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||May be involved in the assembly, secretion and targeting of TGFB1 to sites at which it is stored and/or activated. May play critical roles in controlling and directing the activity of TGFB1. May have a structural role in the extracellular matrix (ECM).|
|Tissue Location||Expressed in the aorta (at protein level). Isoform Long is found in fibroblasts|
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Provided below are standard protocols that you may find useful for product applications.
LTBP1 may be involved in the assembly, secretion and targeting of TGFB1 to sites at which it is stored and/or activated. This protein may play critical roles in controlling and directing the activity of TGFB1, and it may have a structural role in the extra cellular matrix (ECM).
Olofsson A., J. Biol. Chem. 270:31294-31297(1995) Kanzaki T., Cell 61:1051-1061(1990) Isogai Z., J. Biol. Chem. 278:2750-2757(2003) Oklu R., Biochem. J. 352:601-610(2000)
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