LTBP1 Antibody (N-term)
Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| IHC-P, E |
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Primary Accession | Q14766 |
Reactivity | Human |
Host | Rabbit |
Clonality | Polyclonal |
Isotype | Rabbit IgG |
Calculated MW | 186796 Da |
Antigen Region | 295-323 aa |
Gene ID | 4052 |
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Other Names | Latent-transforming growth factor beta-binding protein 1, LTBP-1, Transforming growth factor beta-1-binding protein 1, TGF-beta1-BP-1, LTBP1 |
Target/Specificity | This LTBP1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 295-323 amino acids from the N-terminal region of human LTBP1. |
Dilution | IHC-P~~1:10~50 |
Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS. |
Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | LTBP1 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | LTBP1 (HGNC:6714) |
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Function | Key regulator of transforming growth factor beta (TGFB1, TGFB2 and TGFB3) that controls TGF-beta activation by maintaining it in a latent state during storage in extracellular space (PubMed:2022183, PubMed:8617200, PubMed:8939931). Associates specifically via disulfide bonds with the Latency-associated peptide (LAP), which is the regulatory chain of TGF-beta, and regulates integrin-dependent activation of TGF-beta (PubMed:8617200, PubMed:8939931, PubMed:15184403). Outcompeted by LRRC32/GARP for binding to LAP regulatory chain of TGF-beta (PubMed:22278742). |
Cellular Location | Secreted. Secreted, extracellular space, extracellular matrix |
Tissue Location | Expressed in the aorta (at protein level) (PubMed:17293099). Isoform Long: Expressed in fibroblasts (PubMed:17293099). |
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Provided below are standard protocols that you may find useful for product applications.
Background
LTBP1 may be involved in the assembly, secretion and targeting of TGFB1 to sites at which it is stored and/or activated. This protein may play critical roles in controlling and directing the activity of TGFB1, and it may have a structural role in the extra cellular matrix (ECM).
References
Olofsson A., J. Biol. Chem. 270:31294-31297(1995) Kanzaki T., Cell 61:1051-1061(1990) Isogai Z., J. Biol. Chem. 278:2750-2757(2003) Oklu R., Biochem. J. 352:601-610(2000)
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