|Application ||WB, IHC-P, FC, E|
|Calculated MW||28087 Da|
|Antigen Region||186-212 aa|
|Other Names||WW domain-binding protein 2, WBP-2, WBP2|
|Target/Specificity||This WBP2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 186-212 amino acids from the C-terminal region of human WBP2.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||WBP2 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Acts as transcriptional coactivator of estrogen and progesterone receptors (ESR1 and PGR) upon hormone activation (PubMed:16772533). In presence of estrogen, binds to ESR1- responsive promoters (PubMed:16772533). Required for YAP1 coactivation function on PGR activity (PubMed:16772533). Synergizes with WBP2 in enhancing PGR activity (PubMed:16772533). Modulates expression of post-synaptic scaffolding proteins via regulation of ESR1, ESR2 and PGR (By similarity).|
|Cellular Location||Cytoplasm. Nucleus. Note=Translocates from cytoplasm to nucleus when phosphorylated|
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Provided below are standard protocols that you may find useful for product applications.
The globular WW domain is composed of 38 to 40 semiconserved amino acids shared by proteins of diverse functions including structural, regulatory, and signaling proteins. The domain is involved in mediating protein-protein interactions through the binding of polyproline ligands. WBP2 is a WW domain binding protein, which binds to the WW domain of Yes kinase-associated protein by its PY motifs. The function of this protein has not been determined.
Dhananjayan,S.C., Mol. Endocrinol. 20 (10), 2343-2354 (2006)
Nitsch,R., Biochem. J. 377 (PT 3), 553-560 (2004)
Jolliffe,C.N., Biochem. J. 351 PT 3, 557-565 (2000)
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