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PRKCDBP Antibody (Center)

Purified Rabbit Polyclonal Antibody (Pab)

     
  • WB - PRKCDBP Antibody (Center) AP7787c
    Western blot analysis of anti-PRKCDBP Antibody (Center) (Cat.#AP7787c) in A2058 cell line lysates (35ug/lane). PRKCDBP (arrow) was detected using the purified Pab.
    detail
  • WB - PRKCDBP Antibody (Center) AP7787c
    Western blot analysis of PRKCDBP (arrow) using rabbit polyclonal PRKCDBP Antibody (Center) (Cat. #AP7787c). 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected with the PRKCDBP gene (Lane 2) (Origene Technologies).
    detail
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, E
Primary Accession Q969G5
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit IgG
Calculated MW 27701 Da
Antigen Region 113-144 aa
Additional Information
Gene ID 112464
Other Names Protein kinase C delta-binding protein, Cavin-3, Serum deprivation response factor-related gene product that binds to C-kinase, hSRBC, PRKCDBP, SRBC
Target/Specificity This PRKCDBP antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 113-144 amino acids from the Central region of human PRKCDBP.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsPRKCDBP Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name CAVIN3 (HGNC:9400)
Synonyms PRKCDBP, SRBC
Function Regulates the traffic and/or budding of caveolae (PubMed:19262564). Plays a role in caveola formation in a tissue- specific manner. Required for the formation of caveolae in smooth muscle but not in the lung and heart endothelial cells. Regulates the equilibrium between cell surface-associated and cell surface- dissociated caveolae by promoting the rapid release of caveolae from the cell surface. Plays a role in the regulation of the circadian clock. Modulates the period length and phase of circadian gene expression and also regulates expression and interaction of the core clock components PER1/2 and CRY1/2 (By similarity).
Cellular Location Cytoplasm {ECO:0000250|UniProtKB:Q91VJ2}. Membrane, caveola. Cytoplasm, cytosol {ECO:0000250|UniProtKB:Q91VJ2}. Note=Localizes in the caveolae in a caveolin-dependent manner.
Tissue Location Skeletal muscle, liver, stomach, lung, kidney and heart (at protein level). Strongly expressed in mammary and epithelial cells.
Research Areas
Citations (0)
citation

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Background

PRKCDBP was identified as a binding protein of the protein kinase C, delta (PRKCD). The expression of this protein in cultured cell lines is strongly induced by serum starvation, and was found to be down-regulated in various cancer cell lines, suggesting the possible tumor suppressor function of this protein.

References

Lee,J.H., Int. J. Cancer 122 (7), 1573-1584 (2008)
Zochbauer-Muller,S., Oncogene 24 (41), 6249-6255 (2005)
Xu,X.L., Cancer Res. 61 (21), 7943-7949 (2001)

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$ 182.50
$ 70.00
Cat# AP7787c
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