|Application ||WB, IHC-P, E|
|Calculated MW||53844 Da|
|Antigen Region||7-33 aa|
|Other Names||Cytochrome P450 2W1, 11414-, CYPIIW1, CYP2W1|
|Target/Specificity||This CYP2W1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 7-33 amino acids from the N-terminal region of human CYP2W1.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||CYP2W1 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Seems to have broad catalytic activity towards several chemicals, including polycyclic aromatic hydrocarbon dihydrodiols and aromatic amines (PubMed:16551781, PubMed:24278521). Active also in the metabolism of indoline substrates and is able to activate aflatoxin B1 into cytotoxic products (PubMed:20805301). Furthermore, it seems to be involved in the oxydation of lysophospholipids and fatty acids (PubMed:22591743).|
|Cellular Location||Endoplasmic reticulum lumen. Cell membrane. Note=About 8% are expressed on the cell surface.|
|Tissue Location||Very low levels are detected in fetal and adult tissues. Highly expressed in several tumor samples, in particular colon and adrenal tumors|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
CYP2W1 is a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids.
Gomez,A., Pharmacogenomics 8 (10), 1315-1325 (2007)
Karlgren,M., Biochem. Biophys. Res. Commun. 341 (2), 451-458 (2006)
Nelson,D.R., Pharmacogenetics 14 (1), 1-18 (2004)
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