|Application ||WB, FC, E|
|Calculated MW||122294 Da|
|Antigen Region||145-216 aa|
|Other Names||Desmoglein-2, Cadherin family member 5, HDGC, DSG2, CDHF5|
|Target/Specificity||This DSG2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 145-216 amino acids from the N-terminal region of human DSG2.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||DSG2 Antibody (N-term T160) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion.|
|Cellular Location||Cell membrane; Single-pass type I membrane protein. Cell junction, desmosome|
|Tissue Location||All of the tissues tested and carcinomas.|
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Provided below are standard protocols that you may find useful for product applications.
Desmosomes are cell-cell junctions between epithelial, myocardial, and certain other cell types. This protein is a calcium-binding transmembrane glycoprotein component of desmosomes in vertebrate epithelial cells. Currently, three desmoglein subfamily members have been identified and all are members of the cadherin cell adhesion molecule superfamily. These desmoglein gene family members are located in a cluster on chromosome 18. This second family member is expressed in colon, colon carcinoma, and other simple and stratified epithelial-derived cell lines. Mutations in the DSG2 gene have been associated with arrhythmogenic right ventricular dysplasia, familial, 10.
Posch,M.G., Mol. Genet. Metab. 95 (1-2), 74-80 (2008)
Yu,C.C., J. Formos. Med. Assoc. 107 (7), 548-558 (2008)
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