|Application ||WB, IHC-P, E|
|Calculated MW||11284 Da|
|Antigen Region||45-73 aa|
|Other Names||Apolipoprotein C-II, Apo-CII, ApoC-II, Apolipoprotein C2, Proapolipoprotein C-II, ProapoC-II, APOC2, APC2|
|Target/Specificity||This APOC2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 45-73 amino acids from the Central region of human APOC2.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||APOC2 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Component of chylomicrons, very low-density lipoproteins (VLDL), low-density lipoproteins (LDL), and high-density lipoproteins (HDL) in plasma. Plays an important role in lipoprotein metabolism as an activator of lipoprotein lipase. Both proapolipoprotein C-II and apolipoprotein C-II can activate lipoprotein lipase. In normolipidemic individuals, it is mainly distributed in the HDL, whereas in hypertriglyceridemic individuals, predominantly found in the VLDL and LDL.|
|Tissue Location||Liver and intestine.|
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Provided below are standard protocols that you may find useful for product applications.
APOC2 is secreted in plasma where it is a component of very low density lipoprotein. The protein activates the enzyme lipoprotein lipase, which hydrolyzes triglycerides and thus provides free fatty acids for cells. Mutations in the gene encoding this protein cause hyperlipoproteinemia type IB, characterized by hypertriglyceridemia, xanthomas, and increased risk of pancreatitis and early atherosclerosis.
Bahri,R., Lipids Health Dis 7, 46 (2008) Hegele,R.A., Dis. Markers 9 (2), 73-80 (1991) Bengtsson-Olivecrona,G., Eur. J. Biochem. 192 (2), 515-521 (1990)
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