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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   PHLPP2 Antibody (C-term)   

PHLPP2 Antibody (C-term)

Purified Rabbit Polyclonal Antibody (Pab)

  • WB - PHLPP2 Antibody (C-term) AP7799B
    Western blot analysis of PHLPP2 Antibody (C-term) (Cat. #AP7799b) in MDA-MB231 cell line lysates (35ug/lane).PHLPP2 (arrow) was detected using the purified Pab.
  • IHC-P - PHLPP2 Antibody (C-term) AP7799B
    PHLPP2 Antibody (C-term) (Cat. #AP7799b) IHC analysis in formalin fixed and paraffin embedded colon carcinoma followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of the PHLPP2 Antibody (C-term) for immunohistochemistry. Clinical relevance has not been evaluated.
  • FC - PHLPP2 Antibody (C-term) AP7799B
    PHLPP2 Antibody (C-term) (Cat. #AP7799b) flow cytometric analysis of MDA-MB231 cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q6ZVD8
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 146751 Da
Antigen Region 1295-1323 aa
Additional Information
Gene ID 23035
Other Names PH domain leucine-rich repeat-containing protein phosphatase 2, PH domain leucine-rich repeat-containing protein phosphatase-like, PHLPP-like, PHLPP2, KIAA0931, PHLPPL
Target/Specificity This PHLPP2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1295-1323 amino acids from the C-terminal region of human PHLPP2.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsPHLPP2 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Synonyms KIAA0931, PHLPPL
Function Protein phosphatase that mediates dephosphorylation of 'Ser-473' of AKT1, 'Ser-660' of PRKCB isoform beta-II and 'Ser- 657' of PRKCA. AKT1 regulates the balance between cell survival and apoptosis through a cascade that primarily alters the function of transcription factors that regulate pro- and antiapoptotic genes. Dephosphorylation of 'Ser-473' of AKT1 triggers apoptosis and decreases cell proliferation. Also controls the phosphorylation of AKT3. Dephosphorylation of PRKCA and PRKCB leads to their destabilization and degradation. Inhibits cancer cell proliferation and may act as a tumor suppressor.
Cellular Location Cytoplasm. Membrane; Peripheral membrane protein. Nucleus. Note=In colorectal cancer tissue, expression is concentrated in the cytoplasm and nucleus
Tissue Location In colorectal cancer tissue, expression is highest in the surface epithelium of normal colonic mucosa adjacent to the cancer tissue but is largely excluded from the crypt bases. Expression is lost or significantly decreased in 80% of tested tumors (at protein level)
Research Areas
Citations (0)

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PHLPP2 is a protein phosphatase that specifically mediates dephosphorylation of 'Ser-473' of AKT1. This protein regulates the balance between cell survival and apoptosis through a cascade that primarily alters the function of transcription factors that regulate pro- and antiapoptotic genes. Dephosphorylation of 'Ser-473' of AKT1 triggers apoptosis and decrease cell proliferation. It also controls the phosphorylation of AKT3.


Brognard,J., Mol. Cell 25 (6), 917-931 (2007)

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Cat# AP7799B
(40 western blots)
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