|Application ||WB, IHC-P, E|
|Other Accession||Q924U5, Q8VCT9|
|Calculated MW||63639 Da|
|Antigen Region||210-240 aa|
|Other Names||Dual specificity testis-specific protein kinase 2, Testicular protein kinase 2, TESK2|
|Target/Specificity||This TESK2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 210-240 amino acids from the Central region of human TESK2.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||TESK2 Antibody (Center C225) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Dual specificity protein kinase activity catalyzing autophosphorylation and phosphorylation of exogenous substrates on both serine/threonine and tyrosine residues. Phosphorylates cofilin at 'Ser-3'. May play an important role in spermatogenesis.|
|Tissue Location||Predominantly expressed in testis and prostate. Found predominantly in non-germinal Sertoli cells|
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Provided below are standard protocols that you may find useful for product applications.
TESK2 is a dual specificity protein kinase activity catalyzing autophosphorylation and phosphorylation of exogenous substrates on both serine/threonine and tyrosine residues. TESK2 phosphorylates cofilin at Ser-3. It may play an important role in spermatogenesis. This nuclear enzyme is thought to be activated by autophosphorylation on Ser-219. Expression is predominantly in testis and prostate, with highest concentrations in nongerminal Sertoli cells.
Toshima,J.,J. Biol. Chem. 276 (33), 31449-31458 (2001)
Rosok,O., Genomics 61 (1), 44-54 (1999)
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