|Application ||WB, IHC-P, IF, E|
|Calculated MW||77329 Da|
|Antigen Region||429-458 aa|
|Other Names||Protein-glutamine gamma-glutamyltransferase 2, Tissue transglutaminase, Transglutaminase C, TG(C), TGC, TGase C, Transglutaminase H, TGase H, Transglutaminase-2, TGase-2, TGM2|
|Target/Specificity||This Transglutaminase (TGM2) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 429-458 amino acids from the Central region of human Transglutaminase (TGM2).|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.|
|Precautions||Transglutaminase (TGM2) Antibody (Center K444) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Catalyzes the cross-linking of proteins and the conjugation of polyamines to proteins.|
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Provided below are standard protocols that you may find useful for product applications.
Transglutaminases are enzymes that catalyze the crosslinking of proteins by epsilon-gamma glutamyl lysine isopeptide bonds. While the primary structure of transglutaminases is not conserved, they all have the same amino acid sequence at their active sites and their activity is calcium-dependent. TGM2 acts as a monomer, is induced by retinoic acid, and appears to be involved in apoptosis. It has been identified as the autoantigen implicated in celiac disease.
Porzio,O., Hum. Mutat. 28 (11), 1150 (2007)
Parsons,A.C., Am J Dermatopathol 29 (5), 433-436 (2007)
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