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Gab1 Antibody (Y659)Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
| Country | United States
Ordering Information
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| Catalog # | Size | Availability | Price | |
| AP7832c | 0.1 mg 400 ul | In Stock | $ 255.00 | DISCONTINED INQUIRE CLICK INQUIRE Add to cart |
- Specification
- Citiations : 0
- Reviews
- Protocols
- Backgrounds
Gab1 Antibody (Y659) - Product info | |
| Application | WB, IHC
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| Primary Accession | Q13480 |
| Reactivity | Human |
| Concentration | 0.25 mg/ml |
| Isotype | Rabbit Ig |
| Calculated MW | 76616 Da |
Gab1 Antibody (Y659) - Additional info | |
| Gene ID 2549 | |
| Other Names GAB1; GRB2-associated-binding protein 1; GRB2-associated binder 1; Growth factor receptor bound protein 2-associated protein 1 | |
| Target/Specificity This Gab1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 645~675 amino acids surrounding Y659 of human GAB1. | |
| Dilution WB~~1:100~500WB~~1:1000 IHC~~1:10~50 | |
| Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. | |
| Storage Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. | |
| Precautions Gab1 Antibody (Y659) is for research use only and not for use in diagnostic or therapeutic procedures. | |
Gab1 Antibody (Y659) - Protein Information | |
| Name GAB1 | |
| Function Adapter protein that plays a role in intracellular signaling cascades triggered by activated receptor-type kinases Plays a role in FGFR1 signaling. Probably involved in signaling by the epidermal growth factor receptor (EGFR) and the insulin receptor (INSR) | |
Gab1 Antibody (Y659) - Related products
AP3108a: Phospho-Gab1-Y654 Antibody
AP3109a: Phospho-Gab1-Y627 Antibody
AP3109b: Phospho-Gab1-Y627 Antibody
AP3110a: Gab1 Mutant Y659 Antibody
AP3302b: Phospho-Gab1-Y659 Antibody
AP3599a: Phospho-GAB1-pY259 Antibody
DC08452: Human GAB1 cDNA Clone
BP3108a: Phospho-Gab1-Y654 Antibody Blocking Peptide
BP3109a: Phospho-Gab1-Y627 Antibody Blocking Peptide
BP3109b: Phospho-Gab1-Y627 Antibody Blocking Peptide
BP3110a: Gab1 Mutant Y659 Antibody Blocking Peptide
BP3302b: Phospho-Gab1-Y659 Antibody Blocking Peptide
BP3599a: Phospho-GAB1-pY259 Antibody Blocking Peptide
BP7832b: GAB1 Antibody (Y627) Blocking Peptide
Gab1 Antibody (Y659) - Application data
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Western blot analysis of Gab1 (arrow) using rabbit polyclonal Gab1 Antibody (Y659) (Cat.#AP7832c). 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected with the GAB1 gene (Lane 2) (Origene Technologies).
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Formalin-fixed and paraffin-embedded human breast carcinoma tissue reacted with Gab1 Antibody (Y659) (Cat.#AP7832c), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
Gab1 Antibody (Y659) - Research Areas
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BACKGROUND
GAB1 is a member of the IRS1-like multisubstrate docking protein family. It is an important mediator of branching tubulogenesis and plays a central role in cellular growth response, transformation and apoptosis.
REFERENCES
Seiden-Long,I., Carcinogenesis 29 (3), 647-655 (2008) Oka,M., J. Invest. Dermatol. 128 (1), 188-195 (2008) Laramee,M., J. Biol. Chem. 282 (11), 7758-7769 (2007)
