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SARS Antibody (C-term)
Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| IHC-P, WB, E |
|---|---|
| Primary Accession | P49591 |
| Other Accession | Q6P799, P26638, Q4R4U9, P26636, Q9GMB8, P13642 |
| Reactivity | Human |
| Predicted | Bovine, Hamster, Monkey, Mouse, Rabbit, Rat |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 58777 Da |
| Antigen Region | 394-422 aa |
| Gene ID | 6301 |
|---|---|
| Other Names | Serine--tRNA ligase, cytoplasmic, Seryl-tRNA synthetase, SerRS, Seryl-tRNA(Ser/Sec) synthetase, SARS, SERS |
| Target/Specificity | This SARS antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 394-422 amino acids from the C-terminal region of human SARS. |
| Dilution | WB~~1:1000 IHC-P~~1:10~50 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | SARS Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | SARS1 (HGNC:10537) |
|---|---|
| Synonyms | SARS, SERS |
| Function | Catalyzes the attachment of serine to tRNA(Ser) in a two-step reaction: serine is first activated by ATP to form Ser-AMP and then transferred to the acceptor end of tRNA(Ser) (PubMed:22353712, PubMed:24095058, PubMed:9431993, PubMed:26433229, PubMed:28236339, PubMed:34570399, PubMed:36041817). Is probably also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L- seryl-tRNA(Sec), which will be further converted into selenocysteinyl- tRNA(Sec) (PubMed:9431993, PubMed:26433229, PubMed:28236339, PubMed:34570399). In the nucleus, binds to the VEGFA core promoter and prevents MYC binding and transcriptional activation by MYC (PubMed:24940000). Recruits SIRT2 to the VEGFA promoter, promoting deacetylation of histone H4 at 'Lys-16' (H4K16). Thereby, inhibits the production of VEGFA and sprouting angiogenesis mediated by VEGFA (PubMed:19423848, PubMed:19423847, PubMed:24940000). |
| Cellular Location | Cytoplasm. Nucleus Note=Predominantly cytoplasmic, but a minor proportion is also found in the nucleus. |
| Tissue Location | Brain.. |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
Seryl-tRNA synthetase belongs to the class II amino-acyl tRNA family. This enzyme catalyzes the transfer of L-serine to tRNA (Ser) and is related to bacterial and yeast counterparts.
References
Shimada,N., J. Biol. Chem. 276 (50), 46770-46778 (2001)
Shah,Z.H., Hum. Mutat. 17 (5), 433-434 (2001)
Heckl,M., FEBS Lett. 427 (3), 315-319 (1998)
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