|Application ||WB, E|
|Other Accession||Q4KLA0, P39947, Q62447, P55168, Q3ZCK5|
|Predicted||Bovine, Chicken, Mouse, Rat, Xenopus|
|Calculated MW||33243 Da|
|Antigen Region||221-249 aa|
|Other Names||Cyclin-C, SRB11 homolog, hSRB11, CCNC|
|Target/Specificity||This Cyclin C (CCNC) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 221-249 amino acids from the C-terminal region of human Cyclin C (CCNC).|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||Cyclin C (CCNC) Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Component of the Mediator complex, a coactivator involved in regulated gene transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Binds to and activates cyclin-dependent kinase CDK8 that phosphorylates the CTD (C-terminal domain) of the large subunit of RNA polymerase II (RNAp II), which may inhibit the formation of a transcription initiation complex.|
|Tissue Location||Highest levels in pancreas. High levels in heart, liver, skeletal muscle and kidney. Low levels in brain|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
CCNC is a member of the cyclin family of proteins. This protein interacts with cyclin-dependent kinase 8 and induces the phophorylation of the carboxy-terminal domain of the large subunit of RNA polymerase II.
Katona,R.L., Acta. Biol. Hung. 58 (1), 133-137 (2007)
Ohata,N., Int. J. Mol. Med. 18 (6), 1153-1158 (2006)
Sinkkonen,L., Nucleic Acids Res. 33 (8), 2440-2451 (2005)
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