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>   home   >   Products   >   Primary Antibodies   >   Cell Biology   >   Cyclin C (CCNC) Antibody (C-term)   

Cyclin C (CCNC) Antibody (C-term)

Purified Rabbit Polyclonal Antibody (Pab)

  • WB - Cyclin C (CCNC) Antibody (C-term) AP7835b
    Western blot analysis of anti-CCNC Antibody (C-term) (Cat.#AP7835b) in HL60 cell line lysates (35ug/lane). CCNC(arrow) was detected using the purified Pab.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P24863
Other Accession Q4KLA0, P39947, Q62447, P55168, Q3ZCK5
Reactivity Human
Predicted Bovine, Chicken, Mouse, Rat, Xenopus
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 33243 Da
Antigen Region 221-249 aa
Additional Information
Gene ID 892
Other Names Cyclin-C, SRB11 homolog, hSRB11, CCNC
Target/Specificity This Cyclin C (CCNC) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 221-249 amino acids from the C-terminal region of human Cyclin C (CCNC).
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsCyclin C (CCNC) Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Function Component of the Mediator complex, a coactivator involved in regulated gene transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Binds to and activates cyclin-dependent kinase CDK8 that phosphorylates the CTD (C-terminal domain) of the large subunit of RNA polymerase II (RNAp II), which may inhibit the formation of a transcription initiation complex.
Cellular Location Nucleus.
Tissue Location Highest levels in pancreas. High levels in heart, liver, skeletal muscle and kidney. Low levels in brain
Research Areas
Citations (0)

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CCNC is a member of the cyclin family of proteins. This protein interacts with cyclin-dependent kinase 8 and induces the phophorylation of the carboxy-terminal domain of the large subunit of RNA polymerase II.


Katona,R.L., Acta. Biol. Hung. 58 (1), 133-137 (2007)
Ohata,N., Int. J. Mol. Med. 18 (6), 1153-1158 (2006)
Sinkkonen,L., Nucleic Acids Res. 33 (8), 2440-2451 (2005)

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Cat# AP7835b
(40 western blots)
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