|Application ||WB, E|
|Other Accession||Q4KLA0, P39947, Q62447, P55168, Q3ZCK5|
|Predicted||Bovine, Chicken, Mouse, Rat, Xenopus|
|Calculated MW||33243 Da|
|Antigen Region||221-249 aa|
|Other Names||Cyclin-C, SRB11 homolog, hSRB11, CCNC|
|Target/Specificity||This Cyclin C (CCNC) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 221-249 amino acids from the C-terminal region of human Cyclin C (CCNC).|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.|
|Precautions||Cyclin C (CCNC) Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Component of the Mediator complex, a coactivator involved in regulated gene transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Binds to and activates cyclin-dependent kinase CDK8 that phosphorylates the CTD (C-terminal domain) of the large subunit of RNA polymerase II (RNAp II), which may inhibit the formation of a transcription initiation complex.|
|Tissue Location||Highest levels in pancreas. High levels in heart, liver, skeletal muscle and kidney. Low levels in brain|
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Provided below are standard protocols that you may find useful for product applications.
CCNC is a member of the cyclin family of proteins. This protein interacts with cyclin-dependent kinase 8 and induces the phophorylation of the carboxy-terminal domain of the large subunit of RNA polymerase II.
Katona,R.L., Acta. Biol. Hung. 58 (1), 133-137 (2007)
Ohata,N., Int. J. Mol. Med. 18 (6), 1153-1158 (2006)
Sinkkonen,L., Nucleic Acids Res. 33 (8), 2440-2451 (2005)
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