|Application ||WB, IHC-P, E|
|Calculated MW||56108 Da|
|Antigen Region||318-348 aa|
|Other Names||Aldehyde dehydrogenase family 1 member A3, Aldehyde dehydrogenase 6, Retinaldehyde dehydrogenase 3, RALDH-3, RalDH3, ALDH1A3, ALDH6|
|Target/Specificity||This ALDH1A3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 318-348 amino acids from the Central region of human ALDH1A3.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||ALDH1A3 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Recognizes as substrates free retinal and cellular retinol-binding protein-bound retinal. Seems to be the key enzyme in the formation of an RA gradient along the dorso-ventral axis during the early eye development and also in the development of the olfactory system (By similarity).|
|Tissue Location||Expressed at low levels in many tissues and at higher levels in salivary gland, stomach, and kidney|
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Provided below are standard protocols that you may find useful for product applications.
Aldehyde dehydrogenase isozymes are thought to play a major role in the detoxification of aldehydes generated by alcohol metabolism and lipid peroxidation. The enzyme ALDH1A3 uses retinal as a substrate, either in a free or cellular retinol-binding protein form.
Rexer,B.N., Cancer Res. 61 (19), 7065-7070 (2001) Yoshida,A., Eur. J. Biochem. 251 (3), 549-557 (1998)
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