|Application ||WB, IHC-P, E|
|Calculated MW||98829 Da|
|Antigen Region||717-746 aa|
|Other Names||Cytosolic 10-formyltetrahydrofolate dehydrogenase, 10-FTHFDH, FDH, Aldehyde dehydrogenase family 1 member L1, ALDH1L1, FTHFD|
|Target/Specificity||This ALDH1L1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 717-746 amino acids from the C-terminal region of human ALDH1L1.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||ALDH1L1 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Tissue Location||Highly expressed in liver, pancreas and kidney.|
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Provided below are standard protocols that you may find useful for product applications.
ALDH1L1 catalyzes the conversion of 10-formyltetrahydrofolate, NADP, and water to tetrahydrofolate, NADPH, and carbon dioxide. The encoded protein belongs to the aldehyde dehydrogenase family and is responsible for formate oxidation in vivo. Deficiencies in this gene can result in an accumulation of formate and subsequent methanol poisoning.
Hosgood,H.D. III,Carcinogenesis 29 (10), 1938-1943 (2008)
Lee,K.M., Hum. Genet. 122 (5), 525-533 (2007)
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