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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   ALDH3A1 Antibody (N-term)   

ALDH3A1 Antibody (N-term)

Purified Rabbit Polyclonal Antibody (Pab)

     
  • WB - ALDH3A1 Antibody (N-term) AP7849A
    Western blot analysis of ALDH3A1 (arrow) using rabbit polyclonal ALDH3A1 Antibody (N-term) (Cat.#AP7849a). 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected with the ALDH3A1 gene (Lane 2) (Origene Technologies).
  • IHC-P - ALDH3A1 Antibody (N-term) AP7849A
    Formalin-fixed and paraffin-embedded human lung carcinoma reacted with ALDH3A1 Antibody (N-term), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
  • FC - ALDH3A1 Antibody (N-term) AP7849A
    Flow cytometric analysis of NCI-H292 cells using ALDH3A1 Antibody (N-term)(bottom histogram) compared to a negative control cell (top histogram). FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, FC, E
Primary Accession P30838
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 50395 Da
Antigen Region 69-99 aa
Additional Information
Gene ID 218
Other Names Aldehyde dehydrogenase, dimeric NADP-preferring, ALDHIII, Aldehyde dehydrogenase 3, Aldehyde dehydrogenase family 3 member A1, ALDH3A1, ALDH3
Target/Specificity This ALDH3A1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 69-99 amino acids from the N-terminal region of human ALDH3A1.
Dilution WB~~1:1000
IHC-P~~1:50~100
FC~~1:10~50
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsALDH3A1 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name ALDH3A1
Synonyms ALDH3
Function ALDHs play a major role in the detoxification of alcohol-derived acetaldehyde (Probable). They are involved in the metabolism of corticosteroids, biogenic amines, neurotransmitters, and lipid peroxidation (Probable). Oxidizes medium and long chain aldehydes into non-toxic fatty acids (PubMed:1737758). Preferentially oxidizes aromatic aldehyde substrates (PubMed:1737758). Comprises about 50 percent of corneal epithelial soluble proteins (By similarity). May play a role in preventing corneal damage caused by ultraviolet light (By similarity).
Cellular Location Cytoplasm {ECO:0000250|UniProtKB:P47739}.
Tissue Location High levels in stomach, esophagus and lung; low level in the liver and kidney
Research Areas
Citations (0)

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Background

Aldehyde dehydrogenases oxidize various aldehydes to the corresponding acids. They are involved in the detoxification of alcohol-derived acetaldehyde and in the metabolism of corticosteroids, biogenic amines, neurotransmitters, and lipid peroxidation. ALDH3A1 forms a cytoplasmic homodimer that preferentially oxidizes aromatic and medium-chain (6 carbons or more) saturated and unsaturated aldehyde substrates. The enzyme is thought to promote resistance to UV and 4-hydroxy-2-nonenal-induced oxidative damage in the cornea.

References

Glatt,H., Arch. Biochem. Biophys. 477 (2), 196-205 (2008)
Ekhart,C., Pharmacogenet. Genomics 18 (6), 515-523 (2008)
Giebultowicz,J., Acta Pol Pharm 65 (1), 81-84 (2008)

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Cat# AP7849A
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(40 western blots)
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