- CITATIONS: 1
|Application ||WB, IHC-P, E|
|Calculated MW||50395 Da|
|Antigen Region||254-284 aa|
|Other Names||Aldehyde dehydrogenase, dimeric NADP-preferring, ALDHIII, Aldehyde dehydrogenase 3, Aldehyde dehydrogenase family 3 member A1, ALDH3A1, ALDH3|
|Target/Specificity||This ALDH3A1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 254-284 amino acids from the Central region of human ALDH3A1.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||ALDH3A1 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||ALDHs play a major role in the detoxification of alcohol-derived acetaldehyde. They are involved in the metabolism of corticosteroids, biogenic amines, neurotransmitters, and lipid peroxidation. This protein preferentially oxidizes aromatic aldehyde substrates. It may play a role in the oxidation of toxic aldehydes.|
|Tissue Location||High levels in stomach, esophagus and lung; low level in the liver and kidney|
Provided below are standard protocols that you may find useful for product applications.
Aldehyde dehydrogenases oxidize various aldehydes to the corresponding acids. They are involved in the detoxification of alcohol-derived acetaldehyde and in the metabolism of corticosteroids, biogenic amines, neurotransmitters, and lipid peroxidation. ALDH3A1 forms a cytoplasmic homodimer that preferentially oxidizes aromatic and medium-chain (6 carbons or more) saturated and unsaturated aldehyde substrates. The enzyme is thought to promote resistance to UV and 4-hydroxy-2-nonenal-induced oxidative damage in the cornea.
Glatt,H., Arch. Biochem. Biophys. 477 (2), 196-205 (2008)
Ekhart,C., Pharmacogenet. Genomics 18 (6), 515-523 (2008)
Giebultowicz,J., Acta Pol Pharm 65 (1), 81-84 (2008)
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