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HNRPQ Antibody (C-term)

Purified Rabbit Polyclonal Antibody (Pab)

     
  • WB - HNRPQ Antibody (C-term) AP7852b
    Western blot analysis of HNRPQ Antibody (C-term) (Cat.#AP7852b) in Hela and Jurkat cell line lysates (35ug/lane). HNRPQ (arrow) was detected using the purified Pab.
    detail
  • IHC-P - HNRPQ Antibody (C-term) AP7852b
    Formalin-fixed and paraffin-embedded human brain tissue reacted with HNRPQ antibody (C-term), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
    detail
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
IHC-P, WB, E
Primary Accession O60506
Other Accession Q7TMK9
Reactivity Human
Predicted Mouse
Host Rabbit
Clonality Polyclonal
Isotype Rabbit IgG
Calculated MW 69603 Da
Antigen Region 591-623 aa
Additional Information
Gene ID 10492
Other Names Heterogeneous nuclear ribonucleoprotein Q, hnRNP Q, Glycine- and tyrosine-rich RNA-binding protein, GRY-RBP, NS1-associated protein 1, Synaptotagmin-binding, cytoplasmic RNA-interacting protein, SYNCRIP, HNRPQ, NSAP1
Target/Specificity This HNRPQ antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 591-623 amino acids from the C-terminal region of human HNRPQ.
Dilution WB~~1:1000
IHC-P~~1:10~50
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsHNRPQ Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name SYNCRIP
Synonyms HNRPQ, NSAP1
Function Heterogenous nuclear ribonucleoprotein (hnRNP) implicated in mRNA processing mechanisms. Component of the CRD-mediated complex that promotes MYC mRNA stability. Isoform 1, isoform 2 and isoform 3 are associated in vitro with pre-mRNA, splicing intermediates and mature mRNA protein complexes. Isoform 1 binds to apoB mRNA AU-rich sequences. Isoform 1 is part of the APOB mRNA editosome complex and may modulate the postranscriptional C to U RNA-editing of the APOB mRNA through either by binding to A1CF (APOBEC1 complementation factor), to APOBEC1 or to RNA itself. May be involved in translationally coupled mRNA turnover. Implicated with other RNA-binding proteins in the cytoplasmic deadenylation/translational and decay interplay of the FOS mRNA mediated by the major coding-region determinant of instability (mCRD) domain. Interacts in vitro preferentially with poly(A) and poly(U) RNA sequences. Isoform 3 may be involved in cytoplasmic vesicle-based mRNA transport through interaction with synaptotagmins. Component of the GAIT (gamma interferon-activated inhibitor of translation) complex which mediates interferon-gamma-induced transcript-selective translation inhibition in inflammation processes. Upon interferon-gamma activation assembles into the GAIT complex which binds to stem loop- containing GAIT elements in the 3'-UTR of diverse inflammatory mRNAs (such as ceruplasmin) and suppresses their translation; seems not to be essential for GAIT complex function.
Cellular Location Cytoplasm. Microsome {ECO:0000250|UniProtKB:Q7TMK9} Endoplasmic reticulum. Nucleus {ECO:0000250|UniProtKB:Q7TMK9}. Note=The tyrosine phosphorylated form bound to RNA is found in microsomes (By similarity). Localized in cytoplasmic mRNP granules containing untranslated mRNAs (By similarity). {ECO:0000250|UniProtKB:O43390, ECO:0000250|UniProtKB:Q7TMK9} [Isoform 2]: Nucleus, nucleoplasm {ECO:0000250|UniProtKB:Q7TMK9}. Note=Expressed predominantly in the nucleoplasm. {ECO:0000250|UniProtKB:Q7TMK9}
Tissue Location Ubiquitously expressed. Detected in heart, brain, pancreas, placenta, spleen, lung, liver, skeletal muscle, kidney, thymus, prostate, uterus, small intestine, colon, peripheral blood and testis.
Research Areas
Citations (0)
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Background

Heterogenous nuclear ribonucleoprotein (hnRNP) implicated in mRNA processing mechanisms.

References

Yoo,B.C., Cell. Mol. Life Sci. 66 (2), 350-364 (2009)
Chen,H.H., Mol. Cell. Biol. 28 (22), 6929-6938 (2008)
Quaresma,A.J., Biochem. Biophys. Res. Commun. 350 (2), 288-297 (2006)

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$ 365.00
$ 140.00
Cat# AP7852b
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