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ACHE Antibody (N-term)

Purified Rabbit Polyclonal Antibody (Pab)

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  • WB - ACHE Antibody (N-term) AP7853a
    ACHE Antibody (N-term) (Cat. #AP7853a) western blot analysis in Jurkat,Raji,Y79 cell line lysates (35ug/lane).This demonstrates the ACHE antibody detected the ACHE protein (arrow).
  • IHC-P - ACHE Antibody (N-term) AP7853a
    Formalin-fixed and paraffin-embedded human brain tissue reacted with ACHE antibody (N-term), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
  • FC - ACHE Antibody (N-term) AP7853a
    ACHE Antibody (N-term) (Cat. #AP7853a) flow cytometric analysis of NCI-H460 cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
  • IF - ACHE Antibody (N-term) AP7853a
    Confocal immunofluorescent analysis of ACHE Antibody (N-term)(Cat#AP7853a) with NCI-H460 cell followed by Alexa Fluor 488-conjugated goat anti-rabbit lgG (green).Actin filaments have been labeled with Alexa Fluor 555 phalloidin (red).DAPI was used to stain the cell nuclear (blue).
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P22303
Reactivity Human
Predicted Guinea Pig
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 67796 Da
Antigen Region 147-175 aa
Additional Information
Gene ID 43
Other Names Acetylcholinesterase, AChE, ACHE
Target/Specificity This ACHE antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 147-175 amino acids from the N-terminal region of human ACHE.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsACHE Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Function Terminates signal transduction at the neuromuscular junction by rapid hydrolysis of the acetylcholine released into the synaptic cleft. Role in neuronal apoptosis.
Cellular Location Cell junction, synapse Secreted. Cell membrane; Peripheral membrane protein Isoform H: Cell membrane; Lipid-anchor, GPI-anchor; Extracellular side
Tissue Location Isoform H is highly expressed in erythrocytes.
Research Areas
Citations (0)

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Acetylcholinesterase hydrolyzes the neurotransmitter, acetylcholine at neuromuscular junctions and brain cholinergic synapses, and thus terminates signal transmission. The Protein is also found on the red blood cell membranes, where it constitutes the Yt blood group antigen. Acetylcholinesterase exists in multiple molecular forms which possess similar catalytic properties, but differ in their oligomeric assembly and mode of cell attachment to the cell surface. The major form of acetylcholinesterase found in brain, muscle and other tissues is the hydrophilic species, which forms disulfide-linked oligomers with collagenous, or lipid-containing structural subunits.


Liang,D., FEBS J. 276 (1), 94-108 (2009)
Scacchi,R., Am. J. Med. Genet. B Neuropsychiatr. Genet. (2008)

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Cat# AP7853a
(40 western blots)
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