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COPS3 Antibody (Center)

Purified Rabbit Polyclonal Antibody (Pab)

  • WB - COPS3 Antibody (Center) AP7863c
    Western blot analysis of COPS3 Antibody (Center) (Cat.#AP7863c) in Jurkat, 293 cell line lysates (35ug/lane). COPS3 (arrow) was detected using the purified Pab.
  • WB - COPS3 Antibody (Center) AP7863c
    Western blot analysis of COPS3 (arrow) using rabbit polyclonal COPS3 Antibody (Center) (Cat.#AP7863c). 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected (Lane 2) with the COPS3 gene.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q9UNS2
Other Accession Q68FW9, O88543, Q4R898
Reactivity Human
Predicted Monkey, Mouse, Rat
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 47873 Da
Antigen Region 98-130 aa
Additional Information
Gene ID 8533
Other Names COP9 signalosome complex subunit 3, SGN3, Signalosome subunit 3, JAB1-containing signalosome subunit 3, COPS3, CSN3
Target/Specificity This COPS3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 98-130 amino acids from the Central region of human COPS3.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsCOPS3 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name COPS3
Synonyms CSN3
Function Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively.
Cellular Location Cytoplasm. Nucleus
Tissue Location Widely expressed. Expressed at high level in heart and skeletal muscle.
Research Areas
Citations (0)

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COPS3 possesses kinase activity that phosphorylates regulators involved in signal transduction. This protein phosphorylates I kappa-Balpha, p105, and c-Jun. It acts as a docking site for complex-mediated phosphorylation.


Henriksen J., Aagesen T.H., Maelandsmo G.M.,.Oncogene 22:5358-5361(2003)
Potocki L., Chen K.-S., Lupski J.R.Genomics 57:180-182(1999)
Bech-Otschir D., Kraft R., Huang X.,EMBO J. 20:1630-1639(2001)

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$ 295.00
$ 99.00
Cat# AP7863c
(40 western blots)
Availability: In Stock
Bulk Size
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