|Application ||WB, E|
|Calculated MW||88812 Da|
|Antigen Region||325-356 aa|
|Other Names||AMP deaminase 3, AMP deaminase isoform E, Erythrocyte AMP deaminase, AMPD3|
|Target/Specificity||This AMPD3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 325-356 amino acids from the Central region of human AMPD3.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||AMPD3 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||AMP deaminase plays a critical role in energy metabolism.|
|Tissue Location||Isoform 1 is the predominant form in skeletal muscle; Isoform 2 predominates in smooth muscle, non-muscle tissue, embryonic muscle and undifferentiated myoblasts; Isoform 3 is found in erythrocytes|
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Provided below are standard protocols that you may find useful for product applications.
AMPD3 is a member of the AMP deaminase gene family. This protein is a highly regulated enzyme that catalyzes the hydrolytic deamination of adenosine monophosphate to inosine monophosphate, a branch point in the adenylate catabolic pathway. The protein is the erythrocyte (E) isoforms, whereas other family members isoforms predominate in muscle (M) and liver (L) cells. Mutations in this gene lead to the clinically asymptomatic, autosomal recessive condition erythrocyte AMP deaminase deficiency.
Mahnke-Zizelman D.K., Eddy R.Biochim. Biophys. Acta 1306:75-92(1996)
Yamada Y., Goto H., Wakamatsu N., Ogasawara N.Hum. Mutat. 17:78-78(2001)
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