|Application ||WB, E|
|Other Accession||P62510, P62509|
|Calculated MW||51306 Da|
|Antigen Region||189-221 aa|
|Other Names||Estrogen-related receptor gamma, ERR gamma-2, Estrogen receptor-related protein 3, Nuclear receptor subfamily 3 group B member 3, ESRRG, ERR3, ERRG2, KIAA0832, NR3B3|
|Target/Specificity||This ESRRG antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 189-221 amino acids from the Central region of human ESRRG.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||ESRRG Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||ERR3, ERRG2, KIAA0832, NR3B3|
|Function||Orphan receptor that acts as transcription activator in the absence of bound ligand. Binds specifically to an estrogen response element and activates reporter genes controlled by estrogen response elements (By similarity). Induces the expression of PERM1 in the skeletal muscle.|
|Tissue Location||Expressed in the heart, kidney, brain, lung, bone marrow, adrenal gland, trachea, spinal cord and thyroid gland.|
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Provided below are standard protocols that you may find useful for product applications.
ESRRG is an orphan receptor that acts as transcription activator in the absence of bound ligand. This protein binds specifically to an estrogen response element and activates reporter genes controlled by estrogen response elements.
Chen F., Zhang Q., McDonald T.Gene 228:101-109(1999)
Heard D.J., Norby P.L.Mol. Endocrinol. 14:382-392(2000)
Hong H., Yang L., Stallcup M.R.J. Biol. Chem. 274:22618-22626(1999)
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