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CYP21A2 Antibody (Center)

Purified Rabbit Polyclonal Antibody (Pab)

  • WB - CYP21A2 Antibody (Center) AP7880c
    Western blot analysis of CYP21A2 Antibody (Center) (Cat. #AP7880c) in MDA-MB435 cell line lysates (35ug/lane). CYP21A2 (arrow) was detected using the purified Pab.
  • IHC-P - CYP21A2 Antibody (Center) AP7880c
    Formalin-fixed and paraffin-embedded human breast carcinoma reacted with CYP21A2 Antibody (C-term), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
  • FC - CYP21A2 Antibody (Center) AP7880c
    CYP21A2 Antibody (Center) (Cat. #AP7880c) flow cytometric analysis of MDA-MB231 cells (bottom histogram) compared to a negative control cell (top histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
  • IF - CYP21A2 Antibody (Center) AP7880c
    Confocal immunofluorescent analysis of CYP21A2 Antibody (Center)(Cat#AP7880c) with 293 cell followed by Alexa Fluor 488-conjugated goat anti-rabbit lgG (green). DAPI was used to stain the cell nuclear (blue).
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P08686
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 55887 Da
Antigen Region 216-246 aa
Additional Information
Gene ID 1589
Other Names Steroid 21-hydroxylase, 21-OHase, Cytochrome P-450c21, Cytochrome P450 21, Cytochrome P450 XXI, Cytochrome P450-C21, Cytochrome P450-C21B, CYP21A2, CYP21, CYP21B
Target/Specificity This CYP21A2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 216-246 amino acids from the Central region of human CYP21A2.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsCYP21A2 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name CYP21A2
Synonyms CYP21, CYP21B
Function Specifically catalyzes the 21-hydroxylation of steroids. Required for the adrenal synthesis of mineralocorticoids and glucocorticoids.
Cellular Location Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein
Research Areas
Citations ( 0 )


CYP21A2 is a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and hydroxylates steroids at the 21 position. Its activity is required for the synthesis of steroid hormones including cortisol and aldosterone. Mutations in CYP21A2 gene cause congenital adrenal hyperplasia.


Guerra-Junior,G., Clin. Exp. Immunol. 155 (2), 182-188 (2009) Abid,F., Clin. Chem. Lab. Med. 46 (12), 1707-1713 (2008) Nelson,D.R., Pharmacogenetics 14 (1), 1-18 (2004)

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$ 295.00
$ 99.00
Cat# AP7880c
(40 western blots)
Availability: In Stock
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