|Application ||WB, IHC-P, E|
|Calculated MW||55501 Da|
|Antigen Region||395-424 aa|
|Other Names||Cytochrome P450 2F1, CYPIIF1, CYP2F1|
|Target/Specificity||This CYP2F1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 395-424 amino acids from the C-terminal region of human CYP2F1.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.|
|Precautions||CYP2F1 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||May be involved in the metabolism of various pneumotoxicants including naphthalene. Is able to dealkylate ethoxycoumarin, propoxycoumarin, and pentoxyresorufin but possesses no activity toward ethoxyresorufin and only trace dearylation activity toward benzyloxyresorufin. Bioactivates 3- methylindole (3MI) by dehydrogenation to the putative electrophile 3-methylene-indolenine.|
|Cellular Location||Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein|
|Tissue Location||Expressed in lung. Rarely detected in liver and placenta.|
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Provided below are standard protocols that you may find useful for product applications.
CYP2F1 is a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and is known to dehydrogenate 3-methylindole, an endogenous toxin derived from the fermentation of tryptophan, as well as xenobiotic substrates such as naphthalene and ethoxycoumarin.
Tournel,G., Xenobiotica 37 (12), 1433-1438 (2007)
Tournel,G., Mutat. Res. 617 (1-2), 79-89 (2007)
Nelson,D.R., Pharmacogenetics 14 (1), 1-18 (2004)
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