|Application ||WB, IHC-P, E|
|Calculated MW||57359 Da|
|Antigen Region||464-496 aa|
|Other Names||Vitamin D 25-hydroxylase, Cytochrome P450 2R1, CYP2R1|
|Target/Specificity||This CYP2R1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 464-496 amino acids from the C-terminal region of human CYP2R1.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||CYP2R1 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Has a D-25-hydroxylase activity on both forms of vitamin D, vitamin D(2) and D(3).|
|Cellular Location||Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein|
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Provided below are standard protocols that you may find useful for product applications.
CYP2R1 is a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This enzyme is a microsomal vitamin D hydroxylase that converts vitamin D into the active ligand for the vitamin D receptor. A mutation in CYP2R1 gene has been associated with selective 25-hydroxyvitamin D deficiency.
Ramos-Lopez,E., Diabetes Obes Metab 10 (8), 683-685 (2008)
Strushkevich,N., J. Mol. Biol. 380 (1), 95-106 (2008)
Ramos-Lopez,E., Diabetes Metab. Res. Rev. 23 (8), 631-636 (2007)
Nelson,D.R., Pharmacogenetics 14 (1), 1-18 (2004)
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