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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   CYP2R1 Antibody (Center)   

CYP2R1 Antibody (Center)

Purified Rabbit Polyclonal Antibody (Pab)

     
  • WB - CYP2R1 Antibody (Center) AP7894C
    Western blot analysis of CYP2R1 Antibody (Center) (Cat.#AP7894c) in NCI-H460 cell line(lane 1) and mouse liver tissue(lane 2) lysates (35ug/lane). CYP2R1 (arrow) was detected using the purified Pab.
  • IHC-P - CYP2R1 Antibody (Center) AP7894C
    Formalin-fixed and paraffin-embedded human brain tissue reacted with CYP2R1 antibody (Center), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
  • SPECIFICATION
  • CITATIONS: 1
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, E
Primary Accession Q6VVX0
Reactivity Human, Mouse
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 57359 Da
Antigen Region 152-180 aa
Additional Information
Gene ID 120227
Other Names Vitamin D 25-hydroxylase, Cytochrome P450 2R1, CYP2R1
Target/Specificity This CYP2R1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 152-180 amino acids from the Central region of human CYP2R1.
Dilution WB~~1:1000
IHC-P~~1:10~50
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsCYP2R1 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name CYP2R1
Function Has a D-25-hydroxylase activity on both forms of vitamin D, vitamin D(2) and D(3).
Cellular Location Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein
Research Areas
Citations ( 0 )

Background

CYP2R1 is a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This enzyme is a microsomal vitamin D hydroxylase that converts vitamin D into the active ligand for the vitamin D receptor. A mutation in CYP2R1 gene has been associated with selective 25-hydroxyvitamin D deficiency.

References

Ramos-Lopez,E., Diabetes Obes Metab 10 (8), 683-685 (2008)
Strushkevich,N., J. Mol. Biol. 380 (1), 95-106 (2008)
Ramos-Lopez,E., Diabetes Metab. Res. Rev. 23 (8), 631-636 (2007)
Nelson,D.R., Pharmacogenetics 14 (1), 1-18 (2004)

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$ 295.00
$ 99.00
Cat# AP7894C
Size:
Quantity:
(40 western blots)
Availability: In Stock
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