|Application ||WB, E|
|Calculated MW||60270 Da|
|Antigen Region||473-503 aa|
|Other Names||Cytochrome P450 4F12, CYPIVF12, CYP4F12|
|Target/Specificity||This CYP4F12 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 473-503 amino acids from the C-terminal region of human CYP4F12.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||CYP4F12 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Catalyzes leukotriene B4 omega-hydroxylation and arachidonic acid omega-hydroxylation but with an activity much lower than that of CYP4F2. Catalyzes the hydroxylation of the antihistamine ebastine.|
|Cellular Location||Endoplasmic reticulum membrane; Multi-pass membrane protein Microsome membrane; Multi-pass membrane protein|
|Tissue Location||Expressed in small intestine, liver, colon and heart.|
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Provided below are standard protocols that you may find useful for product applications.
CYP4F12 is a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein likely localizes to the endoplasmic reticulum.
Dhar,M., J. Lipid Res. 49 (3), 612-624 (2008)
Stark,K., Arch. Biochem. Biophys. 441 (2), 174-181 (2005)
Nelson,D.R., Pharmacogenetics 14 (1), 1-18 (2004)
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