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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   ALOX5AP Antibody (Center)   

ALOX5AP Antibody (Center)

Purified Rabbit Polyclonal Antibody (Pab)

  • WB - ALOX5AP Antibody (Center) AP7897c
    Western blot analysis of anti-ALOX5AP Antibody (Center) (Cat.#AP7897c) in K562 cell line lysates (35ug/lane). ALOX5AP(arrow) was detected using the purified Pab.
  • IHC-P - ALOX5AP Antibody (Center) AP7897c
    Formalin-fixed and paraffin-embedded human lung carcinoma tissue reacted with ALOX5AP antibody (Center), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P20292
Other Accession P20291, P30357, P30356, P30355, Q2PG08, Q148F2, P30358
Reactivity Human
Predicted Bovine, Monkey, Mouse, Pig, Rabbit, Rat
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 18157 Da
Antigen Region 86-117 aa
Additional Information
Gene ID 241
Other Names Arachidonate 5-lipoxygenase-activating protein, FLAP, MK-886-binding protein, ALOX5AP, FLAP
Target/Specificity This ALOX5AP antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 86-117 amino acids from the Central region of human ALOX5AP.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsALOX5AP Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Synonyms FLAP
Function Required for leukotriene biosynthesis by ALOX5 (5- lipoxygenase). Anchors ALOX5 to the membrane. Binds arachidonic acid, and could play an essential role in the transfer of arachidonic acid to ALOX5. Binds to MK-886, a compound that blocks the biosynthesis of leukotrienes.
Cellular Location Nucleus membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein
Research Areas
Citations (0)

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ALOX5AP is a protein which, with 5-lipoxygenase, is required for leukotriene synthesis. Leukotrienes are arachidonic acid metabolites which have been implicated in various types of inflammatory responses, including asthma, arthritis and psoriasis. This protein localizes to the plasma membrane. Inhibitors of its function impede translocation of 5-lipoxygenase from the cytoplasm to the cell membrane and inhibit 5-lipoxygenase activation.


Zintzaras,E., Am. J. Epidemiol. 169 (5), 523-532 (2009)
Crosslin,D.R., Hum. Genet. 125 (2), 217-229 (2009)
Steinhilber,D., Pharm Acta Helv 69 (1), 3-14 (1994)

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$ 295.00
$ 99.00
Cat# AP7897c
(40 western blots)
Availability: In Stock
Bulk Size
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