|Application ||WB, IHC-P, E|
|Other Accession||P20291, P30357, P30356, P30355, Q2PG08, Q148F2, P30358|
|Predicted||Bovine, Monkey, Mouse, Pig, Rabbit, Rat, Sheep|
|Calculated MW||18157 Da|
|Antigen Region||86-117 aa|
|Other Names||Arachidonate 5-lipoxygenase-activating protein, FLAP, MK-886-binding protein, ALOX5AP, FLAP|
|Target/Specificity||This ALOX5AP antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 86-117 amino acids from the Central region of human ALOX5AP.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||ALOX5AP Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Required for leukotriene biosynthesis by ALOX5 (5- lipoxygenase). Anchors ALOX5 to the membrane. Binds arachidonic acid, and could play an essential role in the transfer of arachidonic acid to ALOX5. Binds to MK-886, a compound that blocks the biosynthesis of leukotrienes.|
|Cellular Location||Nucleus membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein|
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Provided below are standard protocols that you may find useful for product applications.
ALOX5AP is a protein which, with 5-lipoxygenase, is required for leukotriene synthesis. Leukotrienes are arachidonic acid metabolites which have been implicated in various types of inflammatory responses, including asthma, arthritis and psoriasis. This protein localizes to the plasma membrane. Inhibitors of its function impede translocation of 5-lipoxygenase from the cytoplasm to the cell membrane and inhibit 5-lipoxygenase activation.
Zintzaras,E., Am. J. Epidemiol. 169 (5), 523-532 (2009)
Crosslin,D.R., Hum. Genet. 125 (2), 217-229 (2009)
Steinhilber,D., Pharm Acta Helv 69 (1), 3-14 (1994)
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