- CITATIONS: 2
|Application ||WB, IHC-P, E|
|Calculated MW||103694 Da|
|Antigen Region||628-659 aa|
|Other Names||Mitogen-activated protein kinase kinase kinase 10, Mixed lineage kinase 2, Protein kinase MST, MAP3K10, MLK2, MST|
|Target/Specificity||This MLK2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 628-659 amino acids from the C-terminal region of human MLK2.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||MLK2 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Activates the JUN N-terminal pathway.|
|Tissue Location||Expressed in brain and skeletal muscle.|
Provided below are standard protocols that you may find useful for product applications.
MLK2 is a member of the serine/threonine kinase family. This kinase has been shown to activate MAPK8/JNK and MKK4/SEK1, and this kinase itself can be phoshorylated, and thus activated by JNK kinases. This kinase functions preferentially on the JNK signaling pathway, and is reported to be involved in nerve growth factor (NGF) induced neuronal apoptosis.
Dorow, D.S., et al., Eur. J. Biochem. 234(2):492-500 (1995).
Katoh, M., et al., Oncogene 10(7):1447-1451 (1995).
Dorow, D.S., et al., Eur. J. Biochem. 213(2):701-710 (1993).
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