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MLK2 Antibody (C-term)Purified Rabbit Polyclonal Antibody (Pab)
| Country | United States
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| Catalog # | Size | Availability | Price | |
| AP7920a | 0.1 mg 400 ul | In Stock | $ 255.00 | DISCONTINED INQUIRE CLICK INQUIRE Add to cart |
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MLK2 Antibody (C-term) - Product info | |
| Application | WB, IHC
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| Primary Accession | Q02779 |
| Reactivity | Human |
| Concentration | 0.25 mg/ml |
| Isotype | Rabbit Ig |
| Calculated MW | 103694 Da |
MLK2 Antibody (C-term) - Additional info | |
| Gene ID 4294 | |
| Other Names MAP3K10; MLK2; MST; Mitogen-activated protein kinase kinase kinase 10; Mixed lineage kinase 2; Protein kinase MST | |
| Target/Specificity This MLK2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 636~666 amino acids from the C-terminal region of human MLK2. | |
| Dilution WB~~1:100~500WB~~1:1000 IHC~~1:50~100 | |
| Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS. | |
| Storage Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. | |
| Precautions MLK2 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. | |
MLK2 Antibody (C-term) - Protein Information | |
| Name MAP3K10 | |
| Synonyms MLK2, MST | |
| Function Activates the JUN N-terminal pathway (By similarity). | |
| Tissue Location Expressed in brain and skeletal muscle. | |
MLK2 Antibody (C-term) - Related products
AP7920a: MLK2 Antibody (C-term)
MLK2 Antibody (C-term) - Application data
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The anti-MLK2 Pab (Cat. #AP7920a) is used in Western blot to detect MLK2 in transfected COS7 cell lysate. Data is kindly provided by Drs. M.K. Barthwal and A. Rana from Texas A&M University, Health Science Center (Temple, TX).
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Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. BC = breast carcinoma; HC = hepatocarcinoma.
MLK2 Antibody (C-term) - Research Areas
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Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
MLK2 is a member of the serine/threonine kinase family. This kinase has been shown to activate MAPK8/JNK and MKK4/SEK1, and this kinase itself can be phoshorylated, and thus activated by JNK kinases. This kinase functions preferentially on the JNK signaling pathway, and is reported to be involved in nerve growth factor (NGF) induced neuronal apoptosis.
REFERENCES
Dorow, D.S., et al., Eur. J. Biochem. 234(2):492-500 (1995). Katoh, M., et al., Oncogene 10(7):1447-1451 (1995). Dorow, D.S., et al., Eur. J. Biochem. 213(2):701-710 (1993).
