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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   PKN beta Antibody (C-term)   

PKN beta Antibody (C-term)

Purified Rabbit Polyclonal Antibody (Pab)

  • WB - PKN beta Antibody (C-term) AP7935a
    Western blot analysis of anti-PKN-beta Pab (Cat. #AP7935a) in HeLa cell lysate. PKNbeta (arrow) was detected using purified Pab. Secondary HRP-anti-rabbit was used for signal visualization with chemiluminescence.
  • IHC-P - PKN beta Antibody (C-term) AP7935a
    Formalin-fixed and paraffin-embedded human prostata carcinoma tissue reacted with PKN beta antibody (C-term), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q6P5Z2
Other Accession NP_037487
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 99421 Da
Antigen Region 463-492 aa
Additional Information
Gene ID 29941
Other Names Serine/threonine-protein kinase N3, Protein kinase PKN-beta, Protein-kinase C-related kinase 3, PKN3, PKNBETA
Target/Specificity This PKN beta antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 463-492 amino acids from the C-terminal region of human PKN beta.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsPKN beta Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name PKN3
Synonyms PKNBETA
Function Contributes to invasiveness in malignant prostate cancer.
Cellular Location Nucleus. Cytoplasm, perinuclear region Note=Nuclear and perinuclear Golgi region
Tissue Location Expressed in prostate tumors and various cancer cell lines. Not expressed in adult tissues
Research Areas
Citations (0)

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PKN3, a protein kinase C-related molecule, mediates malignant cell growth downstream of activated PI3K. PKN3 is required for invasive prostate cell growth as assessed by 3D cell culture assays and in an orthotopic mouse tumor model by inducible expression of short hairpin RNA (shRNA). PKN3 is regulated by PI3K at both the expression level and the catalytic activity level. Therefore, PKN3 might represent a preferred target for therapeutic intervention in cancers that lack tumor suppressor PTEN function or depend on chronic activation of PI3K.


Oishi, K., et al., Biochem. Biophys. Res. Commun. 261(3):808-814 (1999).

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$ 295.00
$ 99.00
Cat# AP7935a
(40 western blots)
Availability: In Stock
Bulk Size
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