- CITATIONS: 1
|Application ||WB, IHC-P, E|
|Calculated MW||47604 Da|
|Antigen Region||1-30 aa|
|Other Names||Serine/threonine-protein kinase Sgk2, Serum/glucocorticoid-regulated kinase 2, SGK2|
|Target/Specificity||This SGK2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of human SGK2.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.|
|Precautions||SGK2 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Serine/threonine-protein kinase which is involved in the regulation of a wide variety of ion channels, membrane transporters, cell growth, survival and proliferation. Up- regulates Na(+) channels: SCNN1A/ENAC, K(+) channels: KCNA3/Kv1.3, KCNE1 and KCNQ1, amino acid transporter: SLC6A19, glutamate transporter: SLC1A6/EAAT4, glutamate receptors: GRIA1/GLUR1 and GRIK2/GLUR6, Na(+)/H(+) exchanger: SLC9A3/NHE3, and the Na(+)/K(+) ATPase.|
|Cellular Location||Cytoplasm. Nucleus|
|Tissue Location||Highly expressed in liver, kidney and pancreas, and at lower levels in brain|
Provided below are standard protocols that you may find useful for product applications.
SGK2, a Ser/Thr protein kinase, is similar to serum- and glucocorticoid-induced protein kinase (SGK), but this gene product is not induced by serum or glucocorticoids. Expression is induced in response to signals that activate phosphatidylinositol 3-kinase, which is also true for SGK.
Friedrich, B., et al., Pflugers Arch. 445(6):693-696 (2003).
Embark, H.M., et al., Pflugers Arch. 445(5):601-606 (2003).
Gamper, N., et al., Pflugers Arch. 445(1):60-66 (2002).
Lang, F., et al., Sci. STKE 2001 (108), RE17 (2001).
Kobayashi, T., et al., Biochem. J. 344 Pt 1, 189-197 (1999).
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