|Application ||WB, IHC-P, E|
|Calculated MW||47604 Da|
|Antigen Region||395-426 aa|
|Other Names||Serine/threonine-protein kinase Sgk2, Serum/glucocorticoid-regulated kinase 2, SGK2|
|Target/Specificity||This SGK2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 395-426 amino acids from the C-terminal region of human SGK2.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||SGK2 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Serine/threonine-protein kinase which is involved in the regulation of a wide variety of ion channels, membrane transporters, cell growth, survival and proliferation. Up- regulates Na(+) channels: SCNN1A/ENAC, K(+) channels: KCNA3/Kv1.3, KCNE1 and KCNQ1, amino acid transporter: SLC6A19, glutamate transporter: SLC1A6/EAAT4, glutamate receptors: GRIA1/GLUR1 and GRIK2/GLUR6, Na(+)/H(+) exchanger: SLC9A3/NHE3, and the Na(+)/K(+) ATPase.|
|Cellular Location||Cytoplasm. Nucleus|
|Tissue Location||Highly expressed in liver, kidney and pancreas, and at lower levels in brain|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
SGK2, a Ser/Thr protein kinase, is similar to serum- and glucocorticoid-induced protein kinase (SGK), but this gene product is not induced by serum or glucocorticoids. Expression is induced in response to signals that activate phosphatidylinositol 3-kinase, which is also true for SGK.
Friedrich, B., et al., Pflugers Arch. 445(6):693-696 (2003).
Embark, H.M., et al., Pflugers Arch. 445(5):601-606 (2003).
Gamper, N., et al., Pflugers Arch. 445(1):60-66 (2002).
Lang, F., et al., Sci. STKE 2001 (108), RE17 (2001).
Kobayashi, T., et al., Biochem. J. 344 Pt 1, 189-197 (1999).
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