|Application ||WB, IHC-P, E|
|Other Accession||P70492, O35565|
|Calculated MW||23436 Da|
|Antigen Region||136-165 aa|
|Other Names||Fibroblast growth factor 10, FGF-10, Keratinocyte growth factor 2, FGF10|
|Target/Specificity||This FGF10 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 136-165 amino acids from the C-terminal region of human FGF10.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||FGF10 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Plays an important role in the regulation of embryonic development, cell proliferation and cell differentiation. Required for normal branching morphogenesis. May play a role in wound healing.|
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Provided below are standard protocols that you may find useful for product applications.
FGF10 is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This protein exhibits mitogenic activity for keratinizing epidermal cells, but essentially no activity for fibroblasts, which is similar to the biological activity of FGF7. Studies of the mouse homolog of suggested that this gene is required for embryonic epidermal morphogenesis including brain development, lung morphogenesis, and initiation of lim bud formation. This protein is also implicated to be a primary factor in the process of wound healing.
Nomura,S., Br. J. Cancer 99 (2), 305-313 (2008)
Belleudi,F., Traffic 8 (12), 1854-1872 (2007)
Igarashi,M., J. Biol. Chem. 273 (21), 13230-13235 (1998)
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