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UTS2 Antibody (N-term)
Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| FC, IHC-P, WB, E |
|---|---|
| Primary Accession | O95399 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 14296 Da |
| Antigen Region | 10-39 aa |
| Gene ID | 10911 |
|---|---|
| Other Names | Urotensin-2, Urotensin II, U-II, UII, UTS2 |
| Target/Specificity | This UTS2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 10-39 amino acids from the N-terminal region of human UTS2. |
| Dilution | WB~~1:1000 IHC-P~~1:10~50 FC~~1:10~50 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | UTS2 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | UTS2 |
|---|---|
| Function | Highly potent vasoconstrictor. |
| Cellular Location | Secreted. |
| Tissue Location | Brain specific. |
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Provided below are standard protocols that you may find useful for product applications.
Background
UTS2 is a mature peptide that is an active cyclic heptapeptide absolutely conserved from lamprey to human. The active peptide acts as a vasoconstrictor and is expressed only in brain tissue. Despite the gene family name similarity, this protein is not homologous to urocortin, a member of the sauvagine/corticotropin-releasing factor/urotensin I family. Most of the proprotein is cleaved to make the mature peptide.
References
Brailoiu,E., Peptides 29 (5), 721-726 (2008)
Cirillo,P., J. Thromb. Haemost. 6 (5), 726-736 (2008)
Zoccali,C.Hypertension 51 (2), 326-333 (2008)
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