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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   CYP8A1 Antibody (C-term)   

CYP8A1 Antibody (C-term)

Purified Rabbit Polyclonal Antibody (Pab)

  • WB - CYP8A1 Antibody (C-term) AP7997B
    Western blot analysis of CYP8A1 Antibody (C-term) (Cat. #AP7997b) in CEM cell line lysates (35ug/lane). CYP8A1 (arrow) was detected using the purified Pab.
  • IHC-P - CYP8A1 Antibody (C-term) AP7997B
    Formalin-fixed and paraffin-embedded human prostate carcinoma reacted with CYP8A1 Antibody (C-term) (Cat. #AP7997b), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q16647
Other Accession Q29626
Reactivity Human
Predicted Bovine
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 57104 Da
Antigen Region 472-500 aa
Additional Information
Gene ID 5740
Other Names Prostacyclin synthase, Prostaglandin I2 synthase, PTGIS, CYP8, CYP8A1
Target/Specificity This CYP8A1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 472-500 amino acids from the C-terminal region of human CYP8A1.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsCYP8A1 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Synonyms CYP8, CYP8A1
Function Catalyzes the isomerization of prostaglandin H2 to prostacyclin (= prostaglandin I2).
Cellular Location Endoplasmic reticulum membrane; Single-pass membrane protein
Tissue Location Widely expressed; particularly abundant in ovary, heart, skeletal muscle, lung and prostate
Research Areas
Citations (0)

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CYP8A1 is a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. However, this protein is considered a member of the cytochrome P450 superfamily on the basis of sequence similarity rather than functional similarity. This endoplasmic reticulum membrane protein catalyzes the conversion of prostglandin H2 to prostacyclin (prostaglandin I2), a potent vasodilator and inhibitor of platelet aggregation. An imbalance of prostacyclin and its physiological antagonist thromboxane A2 contribute to the development of myocardial infarction, stroke, and atherosclerosis.


Nelson,D.R., Pharmacogenetics 14 (1), 1-18 (2004)

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Cat# AP7997B
(40 western blots)
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