|Application ||WB, E|
|Calculated MW||97348 Da|
|Antigen Region||392-421 aa|
|Other Names||Phosphoinositide 3-kinase regulatory subunit 5, PI3-kinase regulatory subunit 5, PI3-kinase p101 subunit, Phosphatidylinositol 4, 5-bisphosphate 3-kinase regulatory subunit, PtdIns-3-kinase regulatory subunit, Protein FOAP-2, PtdIns-3-kinase p101, p101-PI3K, PIK3R5|
|Target/Specificity||This PI3KR5 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 392-421 amino acids from the Central region of human PI3KR5.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||PI3KR5 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Regulatory subunit of the PI3K gamma complex. Required for recruitment of the catalytic subunit to the plasma membrane via interaction with beta-gamma G protein dimers. Required for G protein-mediated activation of PIK3CG (By similarity).|
|Cellular Location||Nucleus. Cytoplasm. Membrane; Peripheral membrane protein|
|Tissue Location||Ubiquitously expressed with high expression in fetal brain compared to adult brain. Abundant expression is observed in cerebellum, cerebral cortex, cerebral meninges, and vermis cerebelli.|
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Provided below are standard protocols that you may find useful for product applications.
PI3KR5 is a regulatory subunit of the PI3K gamma complex. This protein, which interacts with G beta gamma proteins, is a heterodimer of a catalytic subunit (PI3KCG/p120) and a regulatory (PI3KR5a/p101) subunit.
Brock, C., et al., J. Cell Biol. 160(1):89-99 (2003).
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