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> home > Products > Antibodies > Biological Process > Cell Differentiation > PIP5KI gamma (PIP5K1G) Antibody (N-term)
PIP5KI gamma (PIP5K1G) Antibody (N-term)Purified Rabbit Polyclonal Antibody (Pab)
| Country | United States
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| Catalog # | Size | Availability | Price | |
| AP8039a | 0.1 mg 400 ul | In Stock | $ 255.00 | DISCONTINED INQUIRE CLICK INQUIRE Add to cart |
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PIP5KI gamma (PIP5K1G) Antibody (N-term) - Product info | |
| Application | WB
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| Primary Accession | O60331 |
| Reactivity | Human |
| Concentration | 0.25 mg/ml |
| Isotype | Rabbit Ig |
| Calculated MW | 73260 Da |
PIP5KI gamma (PIP5K1G) Antibody (N-term) - Additional info | |
| Gene ID 23396 | |
| Other Names PIP5K1C; KIAA0589; Phosphatidylinositol 4-phosphate 5-kinase type-1 gamma; Phosphatidylinositol 4-phosphate 5-kinase type I gamma | |
| Target/Specificity This PIP5K1G antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 34~64 amino acids from the N-terminal region of human PIP5K1G. | |
| Dilution WB~~1:100~500WB~~1:1000 | |
| Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS. | |
| Storage Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. | |
| Precautions PIP5KI gamma (PIP5K1G) Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures. | |
PIP5KI gamma (PIP5K1G) Antibody (N-term) - Protein Information | |
| Name PIP5K1C | |
| Synonyms KIAA0589 | |
| Function Catalyzes the phosphorylation of phosphatidylinositol 4- phosphate (PtdIns4P) to form phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2). PtdIns(4,5)P2 is involved in a variety of cellular processes and is the substrate to form phosphatidylinositol 3,4,5-trisphosphate (PtdIns(3,4,5)P3), another second messenger. The majority of PtdIns(4,5)P2 is thought to occur via type I phosphatidylinositol 4-phosphate 5-kinases given the abundance of PtdIns4P. Participates in a variety of cellular processes such as vesicle mediated transport, cell adhesion, cell polarization and cell migration. Together with PIP5K1A is required for phagocytosis, but they regulate different types of actin remodeling at sequential steps. Promotes particle attachment by generating the pool of PtdIns(4,5)P2 that induces controlled actin depolymerization to facilitate Fc-gamma-R clustering. Mediates RAC1-dependent reorganization of actin filaments. Required for synaptic vesicle transport. Controls the plasma membrane pool of PtdIns(4,5)P2 implicated in synaptic vesicle endocytosis and exocytosis. Plays a role in endocytosis mediated by clathrin and AP-2 (adaptor protein complex 2) Required for clathrin-coated pits assembly at the synapse Participates in cell junction assembly. Modulates adherens junctions formation by facilitating CDH1 trafficking. Required for focal adhesion dynamics. Modulates the targeting of talins (TLN1 and TLN2) to the plasma membrane and their efficient assembly into focal adhesions. Regulates the interaction between talins (TLN1 and TLN2) and beta-integrins. Required for uropodium formation and retraction of the cell rear during directed migration. Has a role in growth factor- stimulated directional cell migration and adhesion. Required for talin assembly into nascent adhesions forming at the leading edge toward the direction of the growth factor. Negative regulator of T-cell activation and adhesion Negatively regulates integrin alpha-L/beta-2 (LFA-1) polarization and adhesion induced by T-cell receptor. Together with PIP5K1A have a role during embryogenesis and together with PIP5K1B may have a role immediately after birth | |
| Cellular Location Cell membrane; Peripheral membrane protein; Cytoplasmic side. Endomembrane system. Cytoplasm. Cell junction, focal adhesion. Cell junction, adherens junction. Cell projection, ruffle membrane. Cell projection, phagocytic cup. Cell projection, uropodium. Note=Detected in plasma membrane invaginations. Isoform 3 is detected in intracellular vesicle-like structures | |
| Tissue Location Isoform 1 is strongly expressed in brain and also detected in heart and lung. Isoform 2 is strongly expressed in pancreas and liver and in lesser quantities in brain, heart, lung and kidney. Isoform 3 is detected in large amounts in heart and large intestine, is also present in lung, pancreas and thyroid, and to a lesser extent in brain, stomach and kidney | |
PIP5KI gamma (PIP5K1G) Antibody (N-term) - Related products
AP8039a: PIP5KI gamma (PIP5K1G) Antibody (N-term)
AP8039b: PIP5KI gamma (PIP5K1G) Antibody (C-term)
RI14017: PIP5K1C predesign siRNA
PIP5KI gamma (PIP5K1G) Antibody (N-term) - Application data
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The anti-PIP5K1G Pab (Cat. #AP8039a) is used in Western blot to detect PIP5K1G in 293 cell lysate.
PIP5KI gamma (PIP5K1G) Antibody (N-term) - Research Areas
AntibodiesBiological ProcessCell DifferentiationNeurogenesisMetabolic ProcessPrimary Metabolic ProcessCellular Metabolic ProcessCellular ProcessLipid Metabolic ProcessSystem DevelopmentMulticellular Organismal DevelopmentAnatomical Structure DevelopmentDevelopmental ProcessCellular Lipid Metabolic ProcessAnatomical Structure MorphogenesisNervous System DevelopmentGeneration Of NeuronsCellular Component OrganizationCellular Developmental ProcessNeuron DifferentiationCell DevelopmentGlycerolipid Metabolic ProcessOrganophosphate Metabolic ProcessPhospholipid Metabolic ProcessGlycerophospholipid Metabolic ProcessNeuron DevelopmentNeuron Projection DevelopmentMulticellular Organismal ProcessCell Projection OrganizationPhosphoinositide Metabolic ProcessPhosphatidylinositol Metabolic ProcessNeuron Projection MorphogenesisAxonogenesisCell Morphogenesis Involved In DifferentiationCell Morphogenesis Involved In Neuron Differentiation
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BACKGROUND
Protein kinases are enzymes that transfer a phosphate group from a phosphate donor, generally the g phosphate of ATP, onto an acceptor amino acid in a substrate protein. By this basic mechanism, protein kinases mediate most of the signal transduction in eukaryotic cells, regulating cellular metabolism, transcription, cell cycle progression, cytoskeletal rearrangement and cell movement, apoptosis, and differentiation. With more than 500 gene products, the protein kinase family is one of the largest families of proteins in eukaryotes. The family has been classified in 8 major groups based on sequence comparison of their tyrosine (PTK) or serine/threonine (STK) kinase catalytic domains.
REFERENCES
Ling, K., et al., Nature 420(6911):89-93 (2002). Di Paolo, G., et al., Nature 420(6911):85-89 (2002). Ishihara, H., et al., J. Biol. Chem. 273(15):8741-8748 (1998).
