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>   home   >   Products   >   Primary Antibodies   >   Neuroscience   >   PBP Antibody (Center)   

PBP Antibody (Center)

Purified Rabbit Polyclonal Antibody (Pab)

     
  • WB - PBP Antibody (Center) AP8092c
    Western blot analysis of anti-PBP Antibody (Center) Antibody (Center) (Cat.#AP8092c) in 293 cell line lysates (35ug/lane). PBP(arrow) was detected using the purified Pab.
  • WB - PBP Antibody (Center) AP8092c
    Western blot analysis of anti-PBP Antibody (Center) (Cat.#AP8092c) in mouse NIH-3T3 tissue lysates (35ug/lane). PBP(arrow) was detected using the purified Pab.
  • IHC-P - PBP Antibody (Center) AP8092c
    Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. BC = breast carcinoma; HC = hepatocarcinoma.
  • WB - PBP Antibody (Center) AP8092c
    Western blot analysis of PBP (arrow) using rabbit polyclonal PBP Antibody (A152) (Cat. #AP8092c). 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected (Lane 2) with the PBP gene.
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, E
Primary Accession P30086
Reactivity Human, Mouse
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 21057 Da
Antigen Region 137-167 aa
Additional Information
Gene ID 5037
Other Names Phosphatidylethanolamine-binding protein 1, PEBP-1, HCNPpp, Neuropolypeptide h3, Prostatic-binding protein, Raf kinase inhibitor protein, RKIP, Hippocampal cholinergic neurostimulating peptide, HCNP, PEBP1, PBP, PEBP
Target/Specificity This PBP antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 137-167 amino acids from the Central region of human PBP.
Dilution WB~~1:1000
IHC-P~~1:50~100
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsPBP Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name PEBP1
Synonyms PBP, PEBP
Function Binds ATP, opioids and phosphatidylethanolamine. Has lower affinity for phosphatidylinositol and phosphatidylcholine. Serine protease inhibitor which inhibits thrombin, neuropsin and chymotrypsin but not trypsin, tissue type plasminogen activator and elastase (By similarity). Inhibits the kinase activity of RAF1 by inhibiting its activation and by dissociating the RAF1/MEK complex and acting as a competitive inhibitor of MEK phosphorylation.
Cellular Location Cytoplasm.
Research Areas
Citations (0)

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Background

PBP binds ATP, opioids and phosphatidylethanolamine, exhibiting a lower affinity for phosphatidylinositol and phosphatidylcholine. This serine protease inhibitor inhibits thrombin, neuropsin and chymotrypsin but not trypsin, tissue type plasminogen activator and elastase. PBP contains hippocampal cholinergic neurostimulating peptide (HCNP), which may be involved in the function of the presynaptic cholinergic neurons of the central nervous system. HCNP increases the production of choline acetyltransferase but not acetylcholinesterase.

References

Tohdoh, N., et al., Brain Res. Mol. Brain Res. 30(2):381-384 (1995). Hori, N., et al., Gene 140(2):293-294 (1994). Seddiqi, N., et al., J. Mol. Evol. 39(6):655-660 (1994). Moore, C., et al., Brain Res. Mol. Brain Res. 37 (1-2), 74-78 (1996).

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$ 295.00
$ 99.00
Cat# AP8092c
Size:
Quantity:
(40 western blots)
Availability: In Stock
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