- CITATIONS: 3
|Application ||IHC-P, E|
|Reactivity||Human, Mouse, Rat|
|Calculated MW||118919 Da|
|Antigen Region||1-30 aa|
|Other Names||Atrial natriuretic peptide receptor 1, Atrial natriuretic peptide receptor type A, ANP-A, ANPR-A, NPR-A, Guanylate cyclase A, GC-A, NPR1, ANPRA|
|Target/Specificity||This Natriuretic Peptide Receptor A antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of human Natriuretic Peptide Receptor A.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||Natriuretic Peptide Receptor A Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Receptor for the atrial natriuretic peptide NPPA/ANP and the brain natriuretic peptide NPPB/BNP which are potent vasoactive hormones playing a key role in cardiovascular homeostasis. Has guanylate cyclase activity upon binding of the ligand.|
|Cellular Location||Membrane; Single-pass type I membrane protein|
Provided below are standard protocols that you may find useful for product applications.
ANPA is a receptor for atrial natriuretic peptide. It exhibits guanylate cyclase activity on binding of ANF. There seem to be at least three ANP receptors: two with guanylate cyclase activity (ANPA and ANPB) and one (ANPC) which is probably responsible for the clearance of ANP from the circulation without a role in signal transduction. This Type I membrane protein belongs to the adenylyl cyclase class-4/guanylyl cyclase family and contains 1 protein kinase-like domain.
Takahashi, Y., et al., Biochem. Biophys. Res. Commun. 246(3):736-739 (1998). Pardhasaradhi, K., et al., Cell. Mol. Neurobiol. 14(1):1-7 (1994). Lowe, D.G., et al., EMBO J. 8(5):1377-1384 (1989).
If you have used an Abgent product and would like to share how it has performed, please click on the "Submit Review" button and provide the requested information. Our staff will examine and post your review and contact you if needed.
If you have any additional inquiries please email technical services at firstname.lastname@example.org.