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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   HK1 Antibody (C-term)   

HK1 Antibody (C-term)

Purified Rabbit Polyclonal Antibody (Pab)

  • WB - HK1 Antibody (C-term) AP8141b
    Western blot analysis of anti-HK1 Antibody (C-term) (Cat. #AP8141b) in A375 cell line lysate. HK1(arrow) was detected using the purified Pab.
  • WB - HK1 Antibody (C-term) AP8141b
    Western blot analysis of HK1 (arrow) using HK1 Antibody (C-term) (Cat.#AP8141b). 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected with the HK1 gene (Lane 2) (Origene Technologies).
  • IHC-P - HK1 Antibody (C-term) AP8141b
    Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. BC = breast carcinoma; HC = hepatocarcinoma.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P19367
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 102486 Da
Antigen Region 705-734 aa
Additional Information
Gene ID 3098
Other Names Hexokinase-1, Brain form hexokinase, Hexokinase type I, HK I, HK1
Target/Specificity This HK1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 705-734 amino acids from the C-terminal region of human HK1.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsHK1 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name HK1
Cellular Location Mitochondrion outer membrane. Note=Its hydrophobic N-terminal sequence may be involved in membrane binding
Tissue Location Isoform 2 is erythrocyte specific. Isoform 3 and isoform 4 are testis-specific
Research Areas
Citations (0)

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Hexokinases phosphorylate glucose to produce glucose-6-phosphate, thus committing glucose to the glycolytic pathway. The hexokinase gene encodes a ubiquitous form of hexokinase which localizes to the outer membrane of mitochondria. Mutations in this gene have been associated with hemolytic anemia due to hexokinase deficiency. Alternative splicing of the hexokinase gene results in five transcript variants which encode different isoforms, some of which are tissue-specific. Each isoform has a distinct N-terminus; the remainder of the protein is identical among all the isoforms. HK1 encodes the ubiquitously expressed isoform. Its 5' end includes an exon which is unique to this transcript and which encodes a distinct N-terminus that contains the porin binding domain (PBD). The porin binding domain mediates association with the mitochondrial membrane.


van Wijk, R., et al., Blood 101(1):345-347 (2003).
Murakami, K., et al., Acta Haematol. 108(4):204-209 (2002).
Murakami, K., et al., Mol. Genet. Metab. 67(2):118-130 (1999).
Aleshin, A.E., et al., Structure 6(1):39-50 (1998).
Ruzzo, A., et al., Blood 91(1):363-364 (1998).

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$ 295.00
$ 99.00
Cat# AP8141b
(40 western blots)
Availability: In Stock
Bulk Size
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