|Application ||IHC-P, WB, E|
|Other Accession||P63102, P63101, Q5ZKC9, P63103, P29361|
|Predicted||Bovine, Chicken, Mouse, Rat, Sheep|
|Calculated MW||27745 Da|
|Antigen Region||211-239 aa|
|Other Names||14-3-3 protein zeta/delta, Protein kinase C inhibitor protein 1, KCIP-1, YWHAZ|
|Target/Specificity||This YWHAZ antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 211-239 amino acids from human YWHAZ.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Precautions||YWHAZ Antibody (T232) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner.|
|Cellular Location||Cytoplasm. Melanosome. Note=Located to stage I to stage IV melanosomes|
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Provided below are standard protocols that you may find useful for product applications.
14-3-3 protein zeta/delta belongs to the 14-3-3 family of proteins which mediate signal transduction by binding to phosphoserine-containing proteins. This protein interacts with IRS1 protein, suggesting a role in regulating insulin sensitivity. This highly conserved protein family is found in both plants and mammals, and this protein is 99% identical to the mouse, rat and sheep orthologs.
Li,F.Q., J. Cell Biol. 181 (7), 1141-1154 (2008)
Mateo,I., Eur. J. Neurol. 15 (3), 219-222 (2008)
Li,Z., Proc. Natl. Acad. Sci. U.S.A. 105 (1), 162-167 (2008)
Powell,D.W., Mol. Cell. Biol. 23 (15), 5376-5387 (2003)
Powell,D.W., J. Biol. Chem. 277 (24), 21639-21642 (2002)
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