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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   YWHAB Antibody (N-term)   

YWHAB Antibody (N-term)

Purified Rabbit Polyclonal Antibody (Pab)

  • WB - YWHAB Antibody (N-term) AP8155a
    The anti-YWHAB Pab (Cat. #AP8155a) is used in Western blot to detect YWHAB in HL-60 cell lysate.
  • IHC-P - YWHAB Antibody (N-term) AP8155a
    Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. BC = breast carcinoma; HC = hepatocarcinoma.
  • WB - YWHAB Antibody (N-term) AP8155a
    Western blot analysis of YWHAB (arrow) using rabbit polyclonal YWHAB Antibody (T71) (Cat. #AP8155a). 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected (Lane 2) with the YWHAB gene.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P31946
Other Accession P35213, Q9CQV8, Q4R572, P68250
Reactivity Human
Predicted Bovine, Monkey, Mouse, Rat
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 28082 Da
Antigen Region 56-85 aa
Additional Information
Gene ID 7529
Other Names 14-3-3 protein beta/alpha, Protein 1054, Protein kinase C inhibitor protein 1, KCIP-1, 14-3-3 protein beta/alpha, N-terminally processed, YWHAB
Target/Specificity This YWHAB antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 56-85 amino acids from the N-terminal region of human YWHAB.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsYWHAB Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Function Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Negative regulator of osteogenesis. Blocks the nuclear translocation of the phosphorylated form (by AKT1) of SRPK2 and antagonizes its stimulatory effect on cyclin D1 expression resulting in blockage of neuronal apoptosis elicited by SRPK2.
Cellular Location Cytoplasm. Melanosome. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV
Research Areas
Citations ( 0 )


YWHAB belongs to the 14-3-3 family of proteins, members of which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals. The encoded protein has been shown to interact with RAF1 and CDC25 phosphatases, suggesting that it may play a role in linking mitogenic signaling and the cell cycle machinery. Two transcript variants differing in the 5' UTR, but encoding the same protein, have been identified for the gene. Both variants encode the same protein, however, they are differentially expressed in hematopoietic cells.


Komori, T., et al., Acta Neuropathol. 106(1):66-70 (2003).
Cavet, M.E., et al., J. Biol. Chem. 278(20):18376-18383 (2003).
Li, Y., et al., J. Biol. Chem. 278(16):13663-13671 (2003).
Shumway, S.D., et al., J. Biol. Chem. 278(4):2089-2092 (2003).
Parvaresch, S., et al., FEBS Lett. 532(3):357-362 (2002).

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$ 295.00
$ 99.00
Cat# AP8155a
(40 western blots)
Availability: In Stock
Bulk Size
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