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Guanylyl Cyclase beta 1 (GUCY1B3) Antibody (C-term)
Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | Q02153 |
| Other Accession | NP_000848 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 70514 Da |
| Antigen Region | 589-619 aa |
| Gene ID | 2983 |
|---|---|
| Other Names | Guanylate cyclase soluble subunit beta-1, GCS-beta-1, Guanylate cyclase soluble subunit beta-3, GCS-beta-3, Soluble guanylate cyclase small subunit, GUCY1B3, GUC1B3, GUCSB3, GUCY1B1 |
| Target/Specificity | This GUCY1B3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected between 589-619 amino acids of human GUCY1B3. |
| Dilution | WB~~1:1000 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | Guanylyl Cyclase beta 1 (GUCY1B3) Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | GUCY1B1 (HGNC:4687) |
|---|---|
| Function | Mediates responses to nitric oxide (NO) by catalyzing the biosynthesis of the signaling molecule cGMP. |
| Cellular Location | Cytoplasm {ECO:0000250|UniProtKB:P16068}. |
| Tissue Location | Detected in brain cortex and cerebellum (at protein level). |
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Provided below are standard protocols that you may find useful for product applications.
Background
Soluble guanylate cyclase (sGC), a heterodimeric protein consisting of an alpha and a beta subunit, catalyzes the conversion of GTP to the second messenger cGMP and functions as the main receptor for nitric oxide and nitrovasodilator drugs.
References
Russwurm, M., et al., J. Biol. Chem. 276(48):44647-44652 (2001).
Lucas, K.A., et al., Pharmacol. Rev. 52(3):375-414 (2000).
Papapetropoulos, A., et al., J. Cell. Physiol. 167(2):213-221 (1996).
Giuili, G., et al., Hum. Genet. 91(3):257-260 (1993).
Giuili, G., et al., FEBS Lett. 304(1):83-88 (1992).
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