|Application ||WB, IHC-P, E|
|Other Accession||Q4L1J4, NP_004733|
|Calculated MW||164581 Da|
|Antigen Region||1227-1256 aa|
|Other Names||Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1, Atrophin-1-interacting protein 3, AIP-3, BAI1-associated protein 1, BAP-1, Membrane-associated guanylate kinase inverted 1, MAGI-1, Trinucleotide repeat-containing gene 19 protein, WW domain-containing protein 3, WWP3, MAGI1, AIP3, BAIAP1, BAP1, TNRC19|
|Target/Specificity||This BAIAP1 (MAGI1) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1227-1256 amino acids from the C-terminal region of human BAIAP1 (MAGI1).|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||BAIAP1 (MAGI1)Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||AIP3, BAIAP1, BAP1, TNRC19|
|Function||May play a role as scaffolding protein at cell-cell junctions. May regulate acid-induced ASIC3 currents by modulating its expression at the cell surface (By similarity).|
|Cellular Location||Cell junction, tight junction. Cell membrane; Peripheral membrane protein. Note=Localizes to epithelial cells tight junctions|
|Tissue Location||Widely expressed with the exception of skeletal muscle. Isoform 1, isoform 2 and isoform 6 are highly expressed in colon, kidney, lung, liver, and pancreas. Isoform 5 is predominantly expressed in brain and heart. Isoform 3 and isoform 4 are highly expressed in pancreas and brain|
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Provided below are standard protocols that you may find useful for product applications.
BAIAP1 is a member of the membrane-associated guanylate kinase homologue (MAGUK) family. Characterized by two WW domains, a guanylate kinase domain, and five PDZ domains, this protein interacts with the cytoplasmic region of BAI1. Together, these proteins may play a role in cell adhesion and signal transduction.
Patrie, K.M., et al., J. Biol. Chem. 277(33):30183-30190 (2002).
Shiratsuchi, T., et al., Biochem. Biophys. Res. Commun. 247(3):597-604 (1998).
Wood, J.D., et al., Mol. Cell. Neurosci. 11(3):149-160 (1998).
Margolis, R.L., et al., Hum. Genet. 100(1):114-122 (1997).
Pirozzi, G., et al., J. Biol. Chem. 272(23):14611-14616 (1997).
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