- CITATIONS: 1
|Application ||WB, IHC-P, E|
|Calculated MW||133281 Da|
|Antigen Region||751-780 aa|
|Other Names||Tyrosine-protein phosphatase non-receptor type 21, Protein-tyrosine phosphatase D1, PTPN21, PTPD1|
|Target/Specificity||This PTPD1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 751-780 amino acids from the Central region of human PTPD1.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||PTPD1 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Cellular Location||Cytoplasm, cytoskeleton.|
Provided below are standard protocols that you may find useful for product applications.
PTPD1 is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains an N-terminal domain, similar to cytoskeletal- associated proteins including band 4.1, ezrin, merlin, and radixin. This PTP was shown to specially interact with BMX/ETK, a member of Tec tyrosine kinase family characterized by a multimodular structures including PH, SH3, and SH2 domains. The interaction of this PTP with BMX kinase was found to increase the activation of STAT3, but not STAT2 kinase. Studies of the similar gene in mice suggested the possible roles of this PTP in liver regeneration and spermatogenesis.
Jui, H.Y., et al., J. Biol. Chem. 275(52):41124-41132 (2000).
Tokuchi, H., et al., Int J Urol 6(11):572-577 (1999).
Higashitsuji, H., et al., Oncogene 10(2):407-414 (1995).
Moller, N.P., et al., Proc. Natl. Acad. Sci. U.S.A. 91(16):7477-7481 (1994).
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