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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   PRL3 Antibody   

PRL3 Antibody

Purified Rabbit Polyclonal Antibody (Pab)

  • WB - PRL3 Antibody AP8438a
    Western blot analysis of PRL3 Antibody (Cat. #AP8438a) in mouse heart tissue lysates (35ug/lane). PRL3 (arrow) was detected using the purified Pab.
  • IHC-P - PRL3 Antibody AP8438a
    Formalin-fixed and paraffin-embedded H.placenta tissue reacted with PRL3 Antibody (Cat#AP8438a).
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession O75365
Other Accession NP_116000
Reactivity Human, Mouse
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 19535 Da
Additional Information
Gene ID 11156
Other Names Protein tyrosine phosphatase type IVA 3, PRL-R, Protein-tyrosine phosphatase 4a3, Protein-tyrosine phosphatase of regenerating liver 3, PRL-3, PTP4A3, PRL3
Target/Specificity This PRL3 antibody is generated from rabbits immunized with a recombinant protein encoding full length of human PRL3.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsPRL3 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name PTP4A3
Synonyms PRL3
Function Protein tyrosine phosphatase which stimulates progression from G1 into S phase during mitosis. Enhances cell proliferation, cell motility and invasive activity, and promotes cancer metastasis. May be involved in the progression of cardiac hypertrophy by inhibiting intracellular calcium mobilization in response to angiotensin II.
Cellular Location Cell membrane. Early endosome
Tissue Location Mainly expressed in cardiomyocytes and skeletal muscle; also found in pancreas. Consistently overexpressed in colon cancer metastasis
Research Areas
Citations (0)

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The protein encoded by this gene belongs to a small class of prenylated protein tyrosine phosphatases (PTPs). PTPs are cell signaling molecules that play regulatory roles in a variety of cellular processes. This class of PTPs contain a PTP domain and a characteristic C-terminal prenylation motif. Studies of this class of PTPs in mice demonstrated that they were prenylated proteins in vivo, which suggested their association with cell plasma membrane. Overexpression of this gene in mammalian cells was reported to inhibit angiotensin-II induced cell calcium mobilization and promote cell growth. Two alternatively spliced variants exist. PRL-3 expression was found to be up-regulated in human liver carcinoma compared with normal liver. Its expression in colorectal cancers may contribute to the establishment of liver metastasis. In a different study, PRL-3 is found to be expressed in tumor metastasis and vasculature, regardless of the tumor source.


Kato,H., et al. Clin. Cancer Res. 10 (21), 7318-7328 (2004)
Wu,X., et al. Am. J. Pathol. 164 (6), 2039-2054 (2004)
Kim,K.A., et al. FEBS Lett. 565 (1-3), 181-187 (2004)
Kozlov,G., et al. J. Biol. Chem. 279 (12), 11882-11889 (2004)
Bardelli,A., eta l. Clin. Cancer Res. 9 (15), 5607-5615 (2003)
Saha,S., et al. Science 294 (5545), 1343-1346 (2001)
Matter,W.F., et al. Biochem. Biophys. Res. Commun. 283 (5), 1061-1068 (2001)
Zeng,Q., et al. J. Biol. Chem. 275 (28), 21444-21452 (2000)
Zeng,Q., et al. Biochem. Biophys. Res. Commun. 244 (2), 421-427 (1998)

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Cat# AP8438a
(40 western blots)
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